Evidence map›Paper›PMID 29354733›Full record

ArticleJournal of spine surgery (Hong Kong)2017

Does timing of transplantation of neural stem cells following spinal cord injury affect outcomes in an animal model?

Ivan Cheng, Don Y Park, Robert E Mayle, Michael Githens, Robert L Smith, Howard Y Park, Serena S Hu, Todd F Alamin, Kirkham B Wood, Alexander I Kharazi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of spine surgery (Hong Kong), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Programmable nanobody circuits for cell selection.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ivan ChengDepartment of Orthopaedic Surgery, Stanford University School of Medicine, Redwood City, CA, USA.
Don Y ParkDepartment of Orthopaedic Surgery, University of California Los Angeles, Santa Monica, CA, USA.
Robert E MayleCalifornia Pacific Orthopaedics and Sports Medicine, San Francisco, CA, USA.
Michael GithensDepartment of Orthopaedic Surgery, University of Washington, Seattle, Washington, USA.
Robert L SmithDepartment of Orthopaedic Surgery, Stanford University School of Medicine, Redwood City, CA, USA.
Howard Y ParkDepartment of Orthopaedic Surgery, University of California Los Angeles, Los Angeles, CA, USA.
Serena S HuDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.
Todd F AlaminDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.
Kirkham B WoodDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.
Alexander I KharaziStemedica, San Diego, CA, USA.
Stanford University · USUniversity of California, Los Angeles · USCalifornia Pacific Medical Center · USUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe previously reported that functional recovery of rats with spinal cord contusions can occur after acute transplantation of neural stem cells distal to the site of injury. To investigate the effects of timing of administration of human neural stem cell (hNSC) distal to the site of spinal cord injury on functional outcomes in an animal model.

methodsThirty-six adult female Long-Evans hooded rats were randomized into three experimental and three control groups with six animals in each group. The T10 level was exposed via posterior laminectomy, and a moderate spinal cord contusion was induced by the Multicenter Animal Spinal Cord Injury Study Impactor (MASCIS, W.M. Keck Center for Collaborative Neuroscience, Piscataway, NJ, USA). The animals received either an intrathecal injection of hNSCs or control media through a separate distal laminotomy immediately, one week or four weeks after the induced spinal cord injury. Observers were blinded to the interventions. Functional assessment was measured immediately after injury and weekly using the Basso, Beattie, Bresnahan (BBB) locomotor rating score.

resultsA statistically significant functional improvement was seen in all three time groups when compared to their controls (acute, mean 9.2

conclusionsThe distal intrathecal transplantation of hNSCs into the contused spinal cord of a rat led to significant functional recovery of the spinal cord when injected in the acute, subacute and chronic phases of spinal cord injury (SCI), although the greatest gains appeared to be in the subacute timing group.

Indexed as

Spinal cord injury (SCI)stem cellstiming

Identifiers

PMID29354733
PMCPMC5760427
OpenAlexW2767556191

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.