ArticleJournal of spine surgery (Hong Kong)2017
Efficacy of tranexamic acid in reducing blood loss and blood transfusion in idiopathic scoliosis: a systematic review and meta-analysis.
Article in Journal of spine surgery (Hong Kong), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Different Dose Regimens of Intravenous Tranexamic Acid in Adolescent Spinal Deformity Surgery: A Systematic Review and Meta-Analysis.BioMed research international · 2020Pooled it
- Pooled it
- Efficacy and safety of tranexamic acid usage in patients undergoing posterior lumbar fusion: a meta-analysis.BMC musculoskeletal disorders · 2019Pooled it
- Postoperative epidural analgesia versus systemic analgesia for thoraco-lumbar spine surgery in children.The Cochrane database of systematic reviews · 2019Pooled it
- No Difference Between Blood Preserving Strategies During Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis.Journal of the Pediatric Orthopaedic Society of North America · 2026Article
- Morbidity and Mortality of Pediatric Spinal Deformity Surgery Using the Japanese Orthopedic Association National Registry/Japanese Society for Spine Surgery and Related Research Database (JOANR/JSSR-DB).Spine surgery and related research · 2025Article
- Minimally Invasive Surgery versus Open Surgery for Adolescent Idiopathic Scoliosis: A Systematic Review and Meta-Analysis.Asian spine journal · 2022Article
- Effectiveness of using tranexamic acid in total hip and total knee arthroplasty: Single tertiary center experience.Saudi medical journal · 2021Article
- [Progress on the application of tranexamic acid in adolescent spine corrective surgery].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020Article
- Use of Intraoperative Tranexamic Acid and Wound Complications in Spine Surgery: A Retrospective Cohort Study.Asian spine journal · 2020Article
- Blood Management and Risk Assessment for Transfusion in Pediatric Spinal Deformity Surgery.Advances in hematology · 2020Article
- Predictors of Hematoma Enlargement in Patients with Spontaneous Intracerebral Hemorrhage Treated with Rapid Administration of Antifibrinolytic Agents and Strict Conservative Management.Korean journal of neurotrauma · 2019Article
- Comparison of Blood-Conserving and Allogenic Transfusion-Sparing Effects of Antifibrinolytics in Scoliosis Correction Surgery.Anesthesia, essays and researchesArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTranexamic acid is a synthetic lysine-analogue antifibrinolytic that competitively inhibits the activation of plasminogen to plasmin, it is a well-documented blood sparing agent. However, its routine use in idiopathic scoliosis surgery is poorly documented. The objective of this meta-analysis was to determine TXA's efficacy in reducing blood loss and blood transfusion in idiopathic scoliosis surgery.
methodsFive databases (Medline, PubMed, Web of Science, Embase and The Cochrane Central Register of Controlled Trials) were searched to identify the relevant randomized controlled trials (RCTs), prospective cohort control (PCC), and retrospective controlled trails regarding the TXA efficacy in idiopathic scoliosis surgery. Mean differences (MDs) of blood loss and blood transfusions in TXA-treated group compared to control and/or placebo group were extracted and combined using random-effect meta-analysis model.
resultsA total of seven studies comprising 426 patients were included in the meta-analysis according to the pre-defined selection criteria. TXA-treated group had an overall significantly (P<0.005) less volume of blood loss [ES (MD) =727.71 mL; CI, 281.86-1,173.56 mL]. Six studies comprising 346 patients TXA-treated group had an overall significantly {P<0.001 less transfusion volume [ES (MD) =268.30 mL; CI, 105.19-431.44 mL]}.
conclusionsPatients treated with TXA had a significantly lower blood loss and lower rates of allogeneic blood transfusion than the control group. Further investigation is required regarding the safety of TXA before it can be generalized in the use of idiopathic scoliosis surgery.
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Registered trials
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