ReviewBMJ open ophthalmology2017
Retinal vasculature in glaucoma: a review.
Review in BMJ open ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 93 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
93 citing papers in PubMed, 2 syntheses or guidelines pooled it, 168 citations in OpenAlex.
- Pooled it
- Diagnostic performance of laser speckle flowgraphy in glaucoma: a systematic review and meta-analysis.International ophthalmology · 2021Pooled it
- Comparison of the Effects of Latanoprostene Bunod and Timolol on Retinal Blood Vessel Density: A Randomized Clinical Trial.American journal of ophthalmology · 2022Trial
- Viscotrabeculotomy versus trabeculectomy in the surgical treatment of open angle glaucoma: a single center, randomised controlled trial.Japanese journal of ophthalmology · 2021Trial
- OCT-angiography: Regional reduced macula microcirculation in ocular hypertensive and pre-perimetric glaucoma patients.PloS one · 2021Trial
- Retinal Arteriosclerosis and Fundus Photograph-Defined Glaucoma in Young Adults: Findings from the Gangnam Eye Cohort.Biomedicines · 2026Article
- Retinal oxygen saturation and retinal vessel diameter in glaucoma patients before and after trabeculectomy.Acta ophthalmologica · 2026Article
- Fundus Stretch Index: A Centile-Based Retinal Measure of Myopia.Ophthalmology science · 2026Article
- Retinomics as a Tool for Glaucoma Prediction.Ophthalmology science · 2026Article
- Alterations in Retinal Vasculometry After Acute Primary Angle Closure Episode: A Comparative Analysis.Translational vision science & technology · 2026Article
- Retinal vascular alteration following surgical intraocular pressure reduction in primary angle closure disease.BMJ open ophthalmology · 2026Article
- Microvascular Volume Loss Exceeds Nerve Fiber Layer but Not Neuroretinal Rim Tissue Loss During Progression of Nonhuman Primate Experimental Glaucoma.Investigative ophthalmology & visual science · 2026Article
- A comparative evaluation of parafoveal and perifoveal macular vessel density loss in glaucoma using 3 × 3 mm OCTA scans.Scientific reports · 2026Article
- Increase of retinal layer thickness in a rat model of acute intraocular hypertension.Experimental eye research · 2026Article
- Selective Receptor Modulation by Truncated Neuropeptide Y (3-36) Dissociates Vasoconstriction from Neuroprotection in Experimental Glaucoma.Molecular neurobiology · 2025Article
- Retinal Neurovascular Coupling: From Mechanisms to a Diagnostic Window into Brain Disorders.Cells · 2025Review
- The effect of habitual sitting posture on peripheral retinal alterations.International ophthalmology · 2025Article
- Non-Invasive Retinal Pathology Assessment Using Haralick-Based Vascular Texture and Global Fundus Color Distribution Analysis.Journal of imaging · 2025Article
- Advanced Age Worsens Phenotypes of Ocular Hypertension in Mice.Aging and disease · 2025Article
- A deep learning model integrating domain-specific features for enhanced glaucoma diagnosis.BMC medical informatics and decision making · 2025Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedCorrection:2018
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the critical impact of glaucoma on global blindness, its aetiology is not fully characterised. Elevated intraocular pressure is highly associated with glaucomatous optic neuropathy. However, visual field loss still progresses in some patients with normal or even low intraocular pressure. Vascular factors have been suggested to play a role in glaucoma development, based on numerous studies showing associations of glaucoma with blood pressure, ocular perfusion pressure, vasospasm, cardiovascular disease and ocular blood flow. As the retinal vasculature is the only part of the human circulation that readily allows non-invasive visualisation of the microcirculation, a number of quantitative retinal vascular parameters measured from retinal photographs using computer software (eg, calibre, fractal dimension, tortuosity and branching angle) are currently being explored for any association with glaucoma and its progression. Several population-based and clinical studies have reported that changes in retinal vasculature (eg, retinal arteriolar narrowing and decreased fractal dimension) are associated with optic nerve damage and glaucoma, supporting the vascular theory of glaucoma pathogenesis. This review summarises recent findings on the relationships between quantitatively measured structural retinal vascular changes with glaucoma and other markers of optic nerve head damage, including retinal nerve fibre layer thickness. Clinical implications, recent new advances in retinal vascular imaging (eg, optical coherence tomography angiography) and future research directions are also discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.