ArticleBMJ open ophthalmology2017
Whole-body positional manipulators for ocular imaging of anaesthetised mice and rats: a do-it-yourself guide.
Article in BMJ open ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Automated animal gimbal steering for retinal imaging and stimulation.Biomedical optics express · 2026Article
- Flecainide mediated sodium channel blockade enhances blood brain barrier integrity and promotes neuroprotection in neuroinflammation.Scientific reports · 2025Article
- Positive allosteric modulation of AMPA receptors via PF4778574 leads to reduced demyelination and clinical disability in experimental models of multiple sclerosis.Frontiers in immunology · 2025Article
- S1PR-1/5 modulator RP-101074 shows beneficial effects in a model of central nervous system degeneration.Frontiers in immunology · 2023Article
- Increased Remyelination and Proregenerative Microglia Under Siponimod Therapy in Mechanistic Models.Neurology(R) neuroimmunology & neuroinflammation · 2022Article
- Semi-Automated Live Tracking of Microglial Activation in CX3CR1Frontiers in immunology · 2021Article
- Comparison of different optomotor response readouts for visual testing in experimental autoimmune encephalomyelitis-optic neuritis.Journal of neuroinflammation · 2020Article
- Neuroprotective Properties of Dimethyl Fumarate Measured by Optical Coherence Tomography in Non-inflammatory Animal Models.Frontiers in neurology · 2020Article
- Monitoring retinal changes with optical coherence tomography predicts neuronal loss in experimental autoimmune encephalomyelitis.Journal of neuroinflammation · 2019Article
- Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model.Journal of neuroinflammation · 2018Article
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Authors and funding
8 authors.
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Abstract
backgroundIn vivo retinal imaging of rodents has gained a growing interest in ophthalmology and neurology. The bedding of the animals with the possibility to perform adjustments in order to obtain an ideal camera-to-eye angle is challenging.
methodsWe provide a guide for a cost-effective, do-it-yourself rodent holder for ocular imaging techniques. The set-up was tested and refined in over 2000 optical coherence tomography measurements of mice and rats.
resultsThe recommended material is very affordable, readily available and easily assembled. The holder can be adapted to both mice and rats. A custom-made mouthpiece is provided for the use of inhalant anaesthesia. The holder is highly functional and assures that the rodent's eye is the centre of rotation for adjustments in both the axial and the transverse planes with a major time benefit over unrestrained positioning of the rodents.
conclusionWe believe this guide is very useful for eye researchers focusing on in vivo retinal imaging in rodents as it significantly reduces examination times for ocular imaging.
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