ArticleGels (Basel, Switzerland)2017
A Bioactive Hydrogel and 3D Printed Polycaprolactone System for Bone Tissue Engineering.
Article in Gels (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed.
- Enhancing bioactivity of 3D-printed porous scaffolds with self-assembling peptide hydrogels for cartilage tissue engineering.3D printing in medicine · 2026Article
- FIBER DIAMETER-DRIVEN MODULATION OF CELL BEHAVIOR IN DECM-ENRICHED ELECTROSPUN SCAFFOLDS FOR BONE TISSUE ENGINEERING.International journal of high speed electronics · 2026Article
- Three-Dimensional Printed Hybrid Scaffolds with Layered Polycaprolactone/Nanosized Smectic Clay Nanocomposite and Chitosan/Collagen/Demineralized Bone Powder Hydrogels Targeting Osteochondral Tissue Engineering.Journal of functional biomaterials · 2025Article
- Growth Factor-Free Engineered Biphasic Scaffold for Enhanced Bone Regeneration.Annals of biomedical engineering · 2025Article
- Advanced Biocompatible and Biodegradable Polymers: A Review of Functionalization, Smart Systems, and Sustainable Applications.Polymers · 2025Review
- Microgel-based bioink for extrusion-based 3D bioprinting and its applications in tissue engineering.Bioactive materials · 2025Review
- 3D-Bioprinted Oil-Based Hydrogels: A Sustainable Approach for Bone and Dental Regeneration.International journal of molecular sciences · 2025Review
- Hybrid Hydrogels Augmented via Additive Network Integration (HANI) for Meniscal Tissue Engineering Applications.Gels (Basel, Switzerland) · 2025Article
- Heterogeneous and Composite Bioinks for 3D-Bioprinting of Complex Tissue.Biomedical materials & devices (New York, N.Y.) · 2025Review
- Development and Characterization of Heparin-Containing Hydrogel/3D-Printed Scaffold Composites for Craniofacial Reconstruction.Annals of biomedical engineering · 2024Article
- The Synergetic Effect of 3D Printing and Electrospinning Techniques in the Fabrication of Bone Scaffolds.Annals of biomedical engineering · 2024Review
- 3D-printed PCL@BG scaffold integrated with SDF-1α-loaded hydrogel for enhancing local treatment of bone defects.Journal of biological engineering · 2024Article
- Biomaterials for extrusion-based bioprinting and biomedical applications.Frontiers in bioengineering and biotechnology · 2024Review
- Hydrogels promote periodontal regeneration.Frontiers in bioengineering and biotechnology · 2024Review
- Towards Polycaprolactone-Based Scaffolds for Alveolar Bone Tissue Engineering: A Biomimetic Approach in a 3D Printing Technique.International journal of molecular sciences · 2023Review
- Design and 3D Printing of Personalized Hybrid and Gradient Structures for Critical Size Bone Defects.ACS applied bio materials · 2023Article
- Long Bone Defect Filling with Bioactive Degradable 3D-Implant: Experimental Study.Biomimetics (Basel, Switzerland) · 2023Article
- Hydrogels-A Promising Materials for 3D Printing Technology.Gels (Basel, Switzerland) · 2023Review
- Recent advances on 3D-printed PCL-based composite scaffolds for bone tissue engineering.Frontiers in bioengineering and biotechnology · 2023Review
- Scaffold Fabrication Techniques of Biomaterials for Bone Tissue Engineering: A Critical Review.Bioengineering (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In this study, a hybrid system consisting of 3D printed polycaprolactone (PCL) filled with hydrogel was developed as an application for reconstruction of long bone defects, which are innately difficult to repair due to large missing segments of bone. A 3D printed gyroid scaffold of PCL allowed a larger amount of hydrogel to be loaded within the scaffolds as compared to 3D printed mesh and honeycomb scaffolds of similar volumes and strut thicknesses. The hydrogel was a mixture of alginate, gelatin, and nano-hydroxyapatite, infiltrated with human mesenchymal stem cells (hMSC) to enhance the osteoconductivity and biocompatibility of the system. Adhesion and viability of hMSC in the PCL/hydrogel system confirmed its cytocompatibility. Biomineralization tests in simulated body fluid (SBF) showed the nucleation and growth of apatite crystals, which confirmed the bioactivity of the PCL/hydrogel system. Moreover, dissolution studies, in SBF revealed a sustained dissolution of the hydrogel with time. Overall, the present study provides a new approach in bone tissue engineering to repair bone defects with a bioactive hybrid system consisting of a polymeric scaffold, hydrogel, and hMSC.
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Registered trials
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