ArticleAnnals of coloproctology2017
Clinical Significance of Signet-Ring-Cell Colorectal Cancer as a Prognostic Factor.
Article in Annals of coloproctology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Breaking Boundaries: An Unusual Case of Rectal Signet Ring Cell Carcinoma Invading the Uterus and Mesentery.Cureus · 2025Article
- Early onset Colorectal Cancer and its association with its histological subtypes.Pakistan journal of medical sciences · 2024Article
- Systematic review of risk factors, prognosis, and management of colorectal signet-ring cell carcinoma.World journal of gastrointestinal oncology · 2024Article
- Observational
- Case report: Preclinical efficacy of NEDD8 and proteasome inhibitors in patient-derived models of signet ring high-grade mucinous colorectal cancer from a Lynch syndrome patient.Frontiers in oncology · 2023Article
- Applications of propensity score matching: a case series of articles published in Annals of Coloproctology.Annals of coloproctology · 2022Review
- Tumor budding as a prognostic indicator in colorectal carcinoma: a retrospective study of primary colorectal carcinoma cases in a tertiary care center.Indian journal of surgical oncology · 2022Article
- Prognosis of Different Histological Types in Patients with Stage II and III Colon Cancer.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Article
- Review
- Predictors of Long-Time Survivors in Nonmetastatic Colorectal Signet Ring Cell Carcinoma: A Large Population-Based Study.Gastroenterology research and practice · 2022Article
- MRI features of signet ring rectal cancer.Abdominal radiology (New York) · 2021Article
- The Impact of Histologic Subtype on Receipt of Adjuvant Chemotherapy and Overall Survival in Stage III Colon Cancer: a Retrospective Cohort Analysis.Journal of gastrointestinal cancer · 2021Article
- Colorectal cancer of the young displays distinct features of aggressive tumor biology: A single-center cohort study.World journal of gastrointestinal surgery · 2021Article
- Clinicopathological factors and survival outcomes of signet-ring cell and mucinous carcinoma versus adenocarcinoma of the colon and rectum: a systematic review and meta-analysis.Discover oncology · 2021Review
- Outcomes of Definitive Treatment of Signet Ring Cell Carcinoma of the Rectum: Is Minimal Invasive Surgery Detrimental in Signet Ring Rectal Cancers?Indian journal of surgical oncology · 2020Article
- Predictive factors of complete pathological response in patients with locally advanced rectal cancer.International journal of colorectal disease · 2020Article
- Aggressive Colorectal Cancer in the Young.Clinics in colon and rectal surgery · 2020Review
- Signet ring cell component in pretreatment biopsy predicts pathological response to preoperative chemoradiotherapy in rectal cancer.International journal of clinical oncology · 2020Article
- Laparoscopic Surgery for Colorectal Cancer in Korea: Nationwide Data from 2013 to 2018.Cancer research and treatment · 2020Article
- Deconvolution of diffuse gastric cancer and the suppression of CD34 on the BALB/c nude mice model.BMC cancer · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study is to evaluate the prognosis for patients with a signet-ring-cell carcinoma (SRCC) who undergo curative surgery by comparing them to patients with an adenocarcinoma (ADC), excluding a mucinous ADC.
methodsBetween September 1994 and December 2013, 14,110 patients with colorectal cancer underwent surgery and among them, 12,631 patients were enrolled in this study. 71 patients with a SRCC and 12,570 patients with a ADC were identified. We analyzed the disease-free survival and the overall survival rates before and after a 1:2 propensity score matching and evaluated those rates after stage stratification.
resultsThe median follow-up durations were 48.5 months for the SRC group and 48.6 months for the ADC group. The disease-free survival rates and the overall survival rates were significantly lower in the SRC group before and after propensity score matching (P < 0.001). After stratification by stage, no differences were observed between the SRC and the ADC groups for the disease-free survival (DFS) and the overall survival (OS) rates for patients with cancer in its early stages (P = 0.913 and P = 0.380 for the DFS and the OS, respectively, in stages 0 and I, and P = 0.223 and P = 0.991 for the DFS and the OS, respectively, in stage II), but those rates were significantly lower in the SRC group for cancer in its later stages (P < 0.001, respectively in stages III and IV).
conclusionFor cancer in advanced stages, patients with a resectable colorectal SRCC had a poorer prognosis after propensity score matching than those with an ADC did. Therefore, more intensive surveillance and closer observation should be offered to such patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.