ArticleClinical psychological science : a journal of the Association for Psychological Science2018
Negative Urgency Mediates the Relation between Genetically-Influenced Serotonin Functioning and Alcohol Problems.
Article in Clinical psychological science : a journal of the Association for Psychological Science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Developmental relations between internalizing symptoms and negative urgency during middle adolescence.Development and psychopathology · 2026Article
- Theoretical Frameworks and Mechanistic Aspects of Alcohol Addiction: Alcohol Addiction as a Reward Deficit/Stress Surfeit Disorder.Current topics in behavioral neurosciences · 2025Review
- Role of Impulsivity in Explaining Social Gradient in Youth Tobacco Use Initiation: Does Race Matter?Open journal of neuroscience · 2024Article
- A trait-like propensity to experience internalizing symptoms is associated with problem alcohol involvement across adulthood, but not adolescence.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020Article
- Dietary yeast influences ethanol sedation in Drosophila via serotonergic neuron function.Addiction biology · 2020Article
- Does Emotion Regulation Predict Gains in Exercise-Induced Fitness? A Prospective Mixed-Effects Study with Elite Helicopter Pilots.International journal of environmental research and public health · 2020Article
- Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency.Frontiers in behavioral neuroscience · 2019Review
- Integrating Preclinical and Clinical Models of Negative Urgency.Frontiers in psychiatry · 2019Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Serotonin (5-HT) functioning is associated with alcohol problems. However, the mechanisms underlying this association remain unclear. The current study tested whether five separate dimensions of impulsivity (UPPS-P) mediated the relation between a polygenic score indexing 5-HT functioning and alcohol problems and whether any of these paths were moderated by age. Results showed that a 5-HT polygenic score predicted alcohol problems indirectly through negative urgency, but not any other facet of impulsivity. The 5-HT polygenic score also directly predicted alcohol problems. No age moderation was found. Findings suggest that negative urgency might be one important mechanism underlying the relation between genetically-influenced 5-HT functioning and alcohol problems. However, genetically-influenced 5-HT functioning likely influences alcohol problems through additional mechanisms. More broadly, results suggest that the previously observed transdiagnostic nature of 5-HT functioning on diverse types of psychopathology might be, in part, explained by its effect on negative urgency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.