ReviewJournal of Istanbul University Faculty of Dentistry2017
A review of regenerative endodontics: current protocols and future directions.
Review in Journal of Istanbul University Faculty of Dentistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Regenerative Endodontic Therapy in the Management of Immature Necrotic Permanent Dentition: A Systematic Review.TheScientificWorldJournal · 2020Pooled it
- Modified apexification with MTA and non-vital bleaching as a comprehensive case management of a necrotic immature tooth: A case report.BMC oral health · 2026Article
- Article
- Bioactive photo-crosslinkable hydrogel based on decellularized dental pulp matrix for functional pulp regeneration.BMC oral health · 2026Article
- Regenerative Endodontics and Stem Cell-Based Therapies - A Systematic Review.Journal of pharmacy & bioallied sciences · 2026Article
- Clinical Application of Inflammatory Vital Pulp Therapy in Immature Permanent Teeth: A Retrospective Case Series.Case reports in dentistry · 2026Article
- Clinical and radiographic evaluation of two different apexification protocols in traumatized immature permanent incisors.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2025Article
- Revascularization of an Immature Three Rooted First Mandibular Molar Using Concentrated Growth Factor: A Case Report.Iranian endodontic journal · 2025Article
- Clinical efficacy of platelet-rich fibrin, injectable platelet-rich fibrin, and advanced platelet-rich fibrin in regenerative endodontics: A case series.Journal of conservative dentistry and endodontics · 2024Article
- Recent Advances in Regenerative Endodontics: A Review of Current Techniques and Future Directions.Cureus · 2024Review
- Retreatment of a Failed Regenerative Endodontic Treatment in an Immature Tooth with a Horizontal Root Fracture: A Case Report.International journal of clinical pediatric dentistry · 2024Article
- Restoring Vitality: The Science and Practice of Pulp Revascularization in Endodontics.Journal of pharmacy & bioallied sciences · 2024Review
- Impact of using XP-endo finisher and nanobubble water during EDTA dentin conditioning on TGF-β1 release in regenerative endodontic procedures.BMC oral health · 2024Article
- Article
- Laser Applications in Regenerative Endodontics: A Review.Journal of lasers in medical sciences · 2024Review
- Unlocking the Potential of Cellular Guidance in Endodontics: Advancing the Process of Pulp Regeneration and Beyond.Cureus · 2024Review
- Microstructure and color stability of calcium silicate-based dental materials exposed to blood or platelet-rich fibrin.Clinical oral investigations · 2023Article
- Influence of periapical lesion size on healing outcome following regenerative endodontic procedures: a clinical investigation.Oral radiology · 2022Article
- Review
- Regenerative Endodontics Success Factors and their Overall Effectiveness: An Umbrella Review.Iranian endodontic journal · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review outlines the biological basis and clinical protocols currently used in regenerative endodontic procedures (REPs) and discuss future directions in pulp regeneration approaches. The treatment of immature teeth with REPs has been described as a 'paradigm shift' as there is the potential for further root maturation. Clinically, REPs involve disinfection of the root canal system without damaging the endogenous stem cell potential present in the apical papilla and other tissues. These stems cells are introduced into the root canal space by inducing a blood clot followed by placement of an intracanal barrier to prevent microleakage. The biological concept of REPs involves the triad of stem cells, scaffold and signalling molecules. Currently, repair rather than true regeneration of the 'pulp-dentine complex' is achieved and further root maturation is variable. However, may clinicians consider the treatment of teeth with REPs as the optimal treatment approach for immature teeth with pulp necrosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.