Evidence map›Paper›PMID 29354291›Full record

ArticleCell death discovery2017

Unacylated ghrelin prevents mitochondrial dysfunction in a model of ischemia/reperfusion liver injury.

Alberto Rossetti, Gabriele Togliatto, Anabela P Rolo, João S Teodoro, Riccarda Granata, Ezio Ghigo, Amedeo Columbano, Carlos M Palmeira, Maria Felice Brizzi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death discovery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 34 citations in OpenAlex.

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  12. [Research progress on the protective effect of Ghrelin on acute and chronic liver injury].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Alberto RossettiDepartment of Medical Sciences, University of Turin, Turin, Italy.
Gabriele TogliattoDepartment of Medical Sciences, University of Turin, Turin, Italy.
Anabela P RoloDepartment of Life Sciences and Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal.
João S TeodoroDepartment of Life Sciences and Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal.ORCID 0000-0002-1244-275X
Riccarda GranataDepartment of Medical Sciences, University of Turin, Turin, Italy.
Ezio GhigoDepartment of Medical Sciences, University of Turin, Turin, Italy.
Amedeo ColumbanoDepartment of Biomedical Sciences, University of Cagliari, 09124 Cagliari, Italy.
Carlos M PalmeiraDepartment of Life Sciences and Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal.
Maria Felice BrizziDepartment of Medical Sciences, University of Turin, Turin, Italy.ORCID 0000-0003-0944-6992
University of Turin · ITUniversity of Coimbra · PTUniversity of Cagliari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemia/reperfusion (I/R) injury is a common cause of liver dysfunction during hepatectomy, liver transplantation procedures and in generalized shock. Although effort has been dedicated to rescuing tissue damage in these clinical settings, there is still an urgent need for an effective treatment to protect the liver from the burden of I/R injury. In this study, we have investigated the potential clinical impact of unacylated-ghrelin (UnAG) in a liver I/R rat model. Particular attention has been paid to mitochondria. We demonstrate that UnAG was able to reduce the lag-phase time in response to ADP administration and increase oxygen consumption in

Identifiers

PMID29354291
PMCPMC5712633
OpenAlexW2773762186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.