ArticleJournal of Korean Neurosurgical Society2018
Novel Genetic Variants Associated with Lumbar Spondylosis in Koreans : A Genome-Wide Association Study.
Article in Journal of Korean Neurosurgical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Contribution of rare variation to degenerative orthopedic diseases.Osteoarthritis and cartilage open · 2026Article
- A common variant rs2054564 in ADAMST17 is associated with susceptibility to lumbar spondylosis.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to identify the susceptibility genes responsible for lumbar spondylosis (LS) in Korean patients.
methodsData from 1427 subjects were made available for radiographic grading and genome wide association studies (GWAS) analysis. Lateral lumbar spine radiographs were obtained and the various degrees of degenerative change were semi-quantitatively scored. A pilot GWAS was performed using the AffymetrixGenome-Wide Human single-nucleotide polymorphisms (SNPs), 500K array. A total of 352228 SNPs were analyzed and the association between the SNPs and case-control status was analyzed by stepwise logistic regression analyses.
resultsThe top 100 SNPs with a cutoff
conclusionWe identified SNPs that potentially contribute to the pathogenesis of LS. This is the first report of a GWAS in an Asian population.
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Registered trials
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