ArticleFrontiers in pharmacology2017
Caffeine Controls Glutamatergic Synaptic Transmission and Pyramidal Neuron Excitability in Human Neocortex.
Article in Frontiers in pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- The Caffeinated Brain Part 1: The Effects of Caffeine on Event-Related Potentials (ERPs)-A Systematic and Mechanistic Review.Nutrients · 2026Pooled it
- Transcranial direct current stimulation combined with caffeine promotes executive function in healthy females.Journal of the International Society of Sports Nutrition · 2025Trial
- Upregulation of adenosine AMolecular psychiatry · 2025Article
- The S-shaped association between dietary caffeine intake and severe headache or migraine: a cross-sectional study based on NHANES.Frontiers in neurology · 2025Article
- Synaptic transmission in supragranular layers of the human cortex - comparative review of structure, function, and plasticity.Frontiers in synaptic neuroscience · 2025Review
- Exploring the singularity of human neurons: keep calm and carry on.Frontiers in synaptic neuroscience · 2025Review
- Food Functional Factors in Alzheimer's Disease Intervention: Current Research Progress.Nutrients · 2024Review
- Association of caffeine consumption with cerebrospinal fluid biomarkers in mild cognitive impairment and Alzheimer's disease: A BALTAZAR cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Adenosinergic Modulation of Layer 6 Microcircuitry in the Medial Prefrontal Cortex Is Specific to Presynaptic Cell Type.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Adenosine AFrontiers in pharmacology · 2024Article
- Pannexin 1 activity in astroglia sets hippocampal neuronal network patterns.PLoS biology · 2022Article
- Article
- Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription.The Journal of clinical investigation · 2022Article
- Caffeine is negatively associated with depression in patients aged 20 and older.Frontiers in psychiatry · 2022Article
- Caffeine Effect on Cognitive Function during a Stroop Task: fNIRS Study.Neural plasticity · 2020Article
- Long-term adult human brain slice cultures as a model system to study human CNS circuitry and disease.eLife · 2019Article
- Caffeine and Selective Adenosine Receptor Antagonists as New Therapeutic Tools for the Motivational Symptoms of Depression.Frontiers in pharmacology · 2018Review
- The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer's Disease.Frontiers in neuroscience · 2018Review
- All-Optical Assay to Study Biological Neural Networks.Frontiers in neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caffeine is the most widely used psychoactive drug, bolstering attention and normalizing mood and cognition, all functions involving cerebral cortical circuits. Whereas studies in rodents showed that caffeine acts through the antagonism of inhibitory A
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.