Evidence map›Paper›PMID 29353939›Full record

ArticleMacromolecules2016

Multi-Stimuli-Responsive Amphiphilic Assemblies through Simple Postpolymerization Modifications.

Xiaochi Liu, Ding Hu, Ziwen Jiang, Jiaming Zhuang, Yisheng Xu, Xuhong Guo, S Thayumanavan

Abstract read
In one paragraph

Article in Macromolecules, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Responsive Supramolecular Polymers for Diagnosis and Treatment.International journal of molecular sciences · 2024
    Review
  2. Article
  3. Sequential intracellular release of water-soluble cargos from Shell-crosslinked polymersomes.Journal of controlled release : official journal of the Controlled Release Society · 2018
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaochi LiuState-Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China.
Ding HuDepartment of Chemistry, University of Massachusetts, Ameherst, Massachusetts 01003, United States.
Ziwen JiangDepartment of Chemistry, University of Massachusetts, Ameherst, Massachusetts 01003, United States.
Jiaming ZhuangDepartment of Chemistry, University of Massachusetts, Ameherst, Massachusetts 01003, United States.
Yisheng XuState-Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China.
Xuhong GuoState-Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China.
S ThayumanavanDepartment of Chemistry, University of Massachusetts, Ameherst, Massachusetts 01003, United States.

Funding

CHEMISTRY-BIOLOGY INTERFACE PREDOCTORAL TRAINING GRANTST32GM008515 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI THOMPSON, LYNMARIE K. · 1995 to 2020
$4.3M
NIGMS NIH HHS T32 GM008515
6 · The paper itself

Abstract

A strategy to construct different stimuli responsive polymers from post polymerization modifications of a single polymer scaffold via thiol-disulfide exchange has been developed. Here, we report on a random copolymer that enables the design and syntheses of a series of dual or multi-stimuli responsive nanoassemblies using a simple post-polymerization modification step. The reactive functional group involves a side chain monopyridyl disulfide unit, which rapidly and quantitatively reacts with various thiols under mild conditions. Independent and concurrent incorporation of physical, chemical or biologically responsive properties have been demonstrated. We envision that this strategy may open up opportunities to simplify the synthesis of multi-functional polymers with broad implications in a variety of biological applications.

Identifiers

PMID29353939
PMCPMC5774634

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.