ArticlePsychological medicine2018
Impaired cognitive plasticity and goal-directed control in adolescent obsessive-compulsive disorder.
Article in Psychological medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Executive functioning in adolescents with internalizing disorders: a systematic review.European child & adolescent psychiatry · 2026Pooled it
- Cognitive Inflexibility in OCD and Related Disorders.Current topics in behavioral neurosciences · 2021Pooled it
- Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder: remediating effects of dopaminergic D2/3 receptor agents.Psychopharmacology · 2019Trial
- The metacognitive paradox of OCD: confidence is globally reduced but shows increased sensitivity to local evidence.Research square · 2025Article
- No Impaired Inhibition of Stimulus-Driven Behavior in Pediatric Obsessive-Compulsive Disorder: a Partial Test of the Habit Formation Model.Research on child and adolescent psychopathology · 2025Article
- Pediatric obsessive-compulsive disorder as a developmental disorder of cognitive-emotional control: a transdiagnostic and family-integrated perspective.Frontiers in psychiatry · 2025Review
- Late development of OCD-like phenotypes in Dlgap1 knockout mice.Psychopharmacology · 2025Article
- The mechanism of social interaction deficits in attention-deficit/hyperactivity disorder children: the role of cognitive flexibility.Frontiers in psychiatry · 2025Article
- A hierarchical reinforcement learning model explains individual differences in attentional set shifting.Cognitive, affective & behavioral neuroscience · 2024Article
- The development of cognitive flexibility and its implications for mental health disorders.Psychological medicine · 2024Article
- Compulsive avoidance in youths and adults with OCD: an aversive pavlovian-to-instrumental transfer study.Translational psychiatry · 2024Article
- Atypical neurocognitive functioning in children and adolescents with obsessive-compulsive disorder (OCD).European child & adolescent psychiatry · 2024Article
- Opening new vistas on obsessive-compulsive disorder with the observing response task.Cognitive, affective & behavioral neuroscience · 2024Review
- Cognitive inflexibility, obsessive-compulsive symptoms and traits and poor post-pandemic adjustment.Neuroscience applied · 2024Review
- Exploring the relationship between context and obsessions in individuals with obsessive-compulsive disorder symptoms: a narrative review.Frontiers in psychiatry · 2024Review
- The Motivational Determinants of Human Action, Their Neural Bases and Functional Impact in Adolescents With Obsessive-Compulsive Disorder.Biological psychiatry global open science · 2023Article
- Mechanisms underlying capsulotomy for refractory obsessive-compulsive disorder: neural correlates of negative affect processing overlap with deep brain stimulation targets.Molecular psychiatry · 2023Article
- Obsessive-compulsive disorder: Etiology, neuropathology, and cognitive dysfunction.Brain and behavior · 2023Review
- Early Identification and Intervention in Pediatric Obsessive-Compulsive Disorder.Brain sciences · 2023Review
- Constitutive depletion of brain serotonin differentially affects rats' social and cognitive abilities.iScience · 2023Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundYouths with obsessive-compulsive disorder (OCD) experience severe distress and impaired functioning at school and at home. Critical cognitive domains for daily functioning and academic success are learning, memory, cognitive flexibility and goal-directed behavioural control. Performance in these important domains among teenagers with OCD was therefore investigated in this study.
methodsA total of 36 youths with OCD and 36 healthy comparison subjects completed two memory tasks: Pattern Recognition Memory (PRM) and Paired Associates Learning (PAL); as well as the Intra-Extra Dimensional Set Shift (IED) task to quantitatively gauge learning as well as cognitive flexibility. A subset of 30 participants of each group also completed a Differential-Outcome Effect (DOE) task followed by a Slips-of-Action Task, designed to assess the balance of goal-directed and habitual behavioural control.
resultsAdolescent OCD patients showed a significant learning and memory impairment. Compared with healthy comparison subjects, they made more errors on PRM and PAL and in the first stages of IED involving discrimination and reversal learning. Patients were also slower to learn about contingencies in the DOE task and were less sensitive to outcome devaluation, suggesting an impairment in goal-directed control.
conclusionsThis study advances the characterization of juvenile OCD. Patients demonstrated impairments in all learning and memory tasks. We also provide the first experimental evidence of impaired goal-directed control and lack of cognitive plasticity early in the development of OCD. The extent to which the impairments in these cognitive domains impact academic performance and symptom development warrants further investigation.
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