Evidence map›Paper›PMID 29353555›Full record

ArticleAddiction science & clinical practice2018

Racial/ethnic differences in the association between alcohol use and mortality among men living with HIV.

Kara M Bensley, Kathleen A McGinnis, David A Fiellin, Adam J Gordon, Kevin L Kraemer, Kendall J Bryant, E Jennifer Edelman, Stephen Crystal, Julie R Gaither, P Todd Korthuis and 7 more

Open access · goldAbstract read
In one paragraph

Article in Addiction science & clinical practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Differences in Receipt of Alcohol-Related Care Across Rurality Among VA Patients Living With HIV With Unhealthy Alcohol Use.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2019
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 1 country.

Kara M BensleyDepartment of Health Services, Magnuson Health Sciences Center, University of Washington School of Public Health, 1959 NE Pacific St, Box 357660, Seattle, WA, 98195-7660, USA. kbensley@uw.edu.
Kathleen A McGinnisVA Connecticut Healthcare System, West Haven Campus, 950 Campbell Avenue, West Haven, CT, 06516, USA.
David A FiellinYale School of Medicine, 333 Cedar St, New Haven, CT, 06510, USA.
Adam J GordonSalt Lake City VA, 500 Foothill Dr, Salt Lake City, UT, 84148, USA.
Kevin L KraemerVA Pittsburgh Healthcare System, University Drive, Pittsburgh, PA, 15240, USA.
Kendall J BryantNational Institute on Alcohol Abuse and Alcoholism, 5635 Fishers Ln, Rockville, MD, 20852, USA.
E Jennifer EdelmanYale School of Medicine, 333 Cedar St, New Haven, CT, 06510, USA.
Stephen CrystalRutgers University, 7 College Ave, New Brunswick, NJ, 08901, USA.
Julie R GaitherVA Connecticut Healthcare System, West Haven Campus, 950 Campbell Avenue, West Haven, CT, 06516, USA.
P Todd KorthuisOregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA.
Brandon D L MarshallBrown University School of Public Health, 121 S Main St, Providence, RI, 02903, USA.
India J OrnelasDepartment of Health Services, Magnuson Health Sciences Center, University of Washington School of Public Health, 1959 NE Pacific St, Box 357660, Seattle, WA, 98195-7660, USA.
K C Gary ChanDepartment of Health Services, Magnuson Health Sciences Center, University of Washington School of Public Health, 1959 NE Pacific St, Box 357660, Seattle, WA, 98195-7660, USA.
Julia C DombrowskiUniversity of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA, 98195, USA.
John C FortneyBrown University School of Public Health, 121 S Main St, Providence, RI, 02903, USA.
Amy C JusticeVA Connecticut Healthcare System, West Haven Campus, 950 Campbell Avenue, West Haven, CT, 06516, USA.
Emily C WilliamsDepartment of Health Services, Magnuson Health Sciences Center, University of Washington School of Public Health, 1959 NE Pacific St, Box 357660, Seattle, WA, 98195-7660, USA.
University of Washington · USYale University · USBrown University · USVA Connecticut Healthcare System · USNational Institute on Alcohol Abuse and Alcoholism · USOregon Health & Science University · USRutgers, The State University of New Jersey · USVA Pittsburgh Healthcare System · USVA Salt Lake City Healthcare System · US

Funding

TREND &STRUCTURE OF ALCOHOL DEPENDENCE--GENERAL POPULATION 1990 SURVEY DATAP50AA005595 · NIAAA · WESTERN CONSORTIUM FOR PUBLIC HEALTH · PI LUI, CAMILLIA K. · 1985 to 2025
$34.1M
Western States Node of the National Drug Abuse Treatment Clinical Trials Network (TMS for CUD) UG1DA015815 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Keith N. Humphreys, Philip Todd Korthuis · 2015 to 2026
$24.6M
Alcohol Associated Outcomes Among HIV+/- Aging VeteransU10AA013566 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2006 to 2010
$12.7M
Alcohol and Multisubstance Use in the Veterans Aging Cohort StudyU01AA020790 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$7.7M
GRADUATE RESEARCH TRAINING ON ALCOHOL PROBLEMST32AA007240 · NIAAA · UNIVERSITY OF CALIFORNIA BERKELEY · PI William C. Kerr · 1985 to 2026
$7.5M
Sex Disparities in Overall Response to ART Among HIV Infected IndividualsU24AA020794 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$5.5M
Integrated Stepped Care for Unhealthy Alcohol Use in HIVU01AA020795 · NIAAA · YALE UNIVERSITY · PI FIELLIN, DAVID · 2011 to 2020
$5.2M
Consortium to improve Outcomes in HIV/AIDS, Alcohol, Aging & multi-Substance useU01AA020799 · NIAAA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BRAITHWAITE, RONALD SCOTT · 2011 to 2020
$2.1M
NIAAA NIH HHS P50 AA005595NIAAA NIH HHS T32 AA007240NIAAA NIH HHS U01 AA020790NIAAA NIH HHS U01 AA020795NIAAA NIH HHS U01 AA020799NIAAA NIH HHS U10 AA013566NIAAA NIH HHS U24 AA020794NIDA NIH HHS UG1 DA015815U.S. Department of Veterans Affairs CDA 12-276
6 · The paper itself

Abstract

backgroundIncreasing alcohol use is associated with increased risk of mortality among patients living with HIV (PLWH). This association varies by race/ethnicity among general outpatients, but racial/ethnic variation has not been investigated among PLWH, among whom racial/ethnic minorities are disproportionately represented.

methodsVA electronic health record data from the Veterans Aging Cohort Study (2008-2012) were used to describe and compare mortality rates across race/ethnicity and levels of alcohol use defined by the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) questionnaire. Within each racial/ethnic group, Cox proportional hazards models, adjusted for age, disease severity, and comorbidities, compared mortality risk for moderate-risk (AUDIT-C = 4-7) and high-risk (AUDIT-C ≥ 8) relative to lower-risk (AUDIT-C = 1-3) alcohol use.

resultsMean follow-up time among black (n = 8518), Hispanic (n = 1353), and white (n = 7368) male PLWH with documented AUDIT-C screening (n = 17,239) was 4.3 years. Black PLWH had the highest mortality rate among patients reporting lower-risk alcohol use (2.9/100 person-years) relative to Hispanic and white PLWH (1.8 and 2.3, respectively) (p value for overall comparison = 0.011). Mortality risk was increased for patients reporting high-risk relative to lower-risk alcohol use in all racial/ethnic groups [black adjusted hazard ratio (AHR) = 1.36, 95% confidence interval (CI) 1.12-1.66; Hispanic AHR = 2.18, 95% CI 1.30-3.64; and white AHR = 2.04, 95% CI 1.61-2.58]. For only white PLWH, mortality risk was increased for patients reporting moderate-relative to lower-risk alcohol use (black AHR = 1.09, 95% CI 0.93-1.27; Hispanic AHR = 1.36, 95% CI 0.89-2.09; white AHR = 1.51, 95% CI 1.28-1.77).

conclusionAmong all PLWH, mortality risk was increased among patients reporting high-risk alcohol use across all racial/ethnic groups, but mortality risk was only increased among patients reporting moderate-risk relative to lower-risk alcohol use among white PLWH, and black patients appeared to have higher mortality risk relative to white patients at lower-risk levels of alcohol use. Findings of the present study further underscore the need to address unhealthy alcohol use among PLWH, and future research is needed to understand mechanisms underlying observed differences.

Indexed as

AgedAge FactorsAlcohol DrinkingAlcoholismBlack or African AmericanComorbidityEthnicityHispanic or LatinoHIV InfectionsHumansMaleMiddle AgedProportional Hazards ModelsRacial GroupsSeverity of Illness IndexUnited StatesAlcohol useHIVMortality riskRacial/ethnic disparitiesVeterans

Identifiers

PMID29353555
PMCPMC6389249
OpenAlexW2783283688

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.