Evidence map›Paper›PMID 29353417›Full record

ArticleIrish journal of medical science2018

Maternal metabolic response to dietary treatment for impaired glucose tolerance and gestational diabetes mellitus.

Karen L Lindsay, Lorraine Brennan, Maria A Kennelly, Sinéad Curran, Mary Coffey, Thomas P Smith, Michael E Foley, Mensud Hatunic, Fionnuala M McAuliffe

Abstract read
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Article in Irish journal of medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Karen L LindsayUCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Holles Street, Dublin 2, Ireland.
Lorraine BrennanUCD Institute of Food and Health, School of Food Science and Veterinary Medicine, University College Dublin, Dublin 4, Ireland.
Maria A KennellyUCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Holles Street, Dublin 2, Ireland.
Sinéad CurranDepartment of Clinical Nutrition, National Maternity Hospital, Holles Street, Dublin 2, Ireland.
Mary CoffeyDepartment of Midwifery, National Maternity Hospital, Holles Street, Dublin 2, Ireland.
Thomas P SmithDepartment of Clinical Chemistry, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Michael E FoleyUCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Holles Street, Dublin 2, Ireland.
Mensud HatunicDepartment of Endocrinology, National Maternity Hospital, Holles Street, Dublin 2, Ireland.
Fionnuala M McAuliffeUCD Perinatal Research Centre, School of Medicine, University College Dublin, National Maternity Hospital, Holles Street, Dublin 2, Ireland. fionnuala.mcauliffe@ucd.ie.ORCID http://orcid.org/0000-0002-3477-6494
University College Dublin · IENational Maternity Hospital · IESt. Vincent's University Hospital · IE

Funding

National Maternity Hospital Fund Ivo Drury awardProject Early Nutrition 289346Seventh Framework Programme na
6 · The paper itself

Abstract

backgroundDietary advice is a standard component of treatment for pregnant women with impaired glucose tolerance (IGT) and gestational diabetes (GDM), yet few studies report glycemic profiles in response to dietary therapies and the optimal dietary approach remains uncertain.

aimTo assess changes in maternal glycemic profile and pregnancy outcomes among women with diet-controlled IGT and GDM.

methodsPregnant women who had one or more elevated values on a 3-h oral glucose tolerance test were enrolled. All participants received dietary advice and glucose monitoring as part of routine clinical care. Fasting and 1-h post-prandial blood samples, collected prior to initiation of clinical treatment and repeated 4-6 weeks later, were analyzed for glucose, insulin, and C-peptide. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Women who required pharmacological therapy for glucose control were excluded from analyses.

resultsParticipants (N = 93) were of moderately older age (mean 33 years), with a high rate of overweight/obesity (mean body mass index (BMI) = 28.65 kg/m

conclusionsAlthough improvements in blood glucose levels were observed among women with diet-controlled IGT and GDM, this was insufficient to significantly affect insulin resistance or perinatal outcome. Late diagnosis and treatment of IGT/GDM may have contributed to such outcomes.

Indexed as

AdultBlood GlucoseDiabetes, GestationalFemaleGlucose IntoleranceGlucose Tolerance TestHumansNutrition TherapyPregnancyBlood GlucoseDiet therapyGestational diabetesGlycemic controlInsulin resistanceMacrosomiaNutrition therapyPregnancy

Identifiers

PMID29353417
OpenAlexW2790492744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.