ReviewBiophysical reviews2018
The multiple roles of titin in muscle contraction and force production.
Review in Biophysical reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it, 168 citations in OpenAlex.
- Acute Effects of Accentuated Eccentric Loading on Mean Concentric Velocity During Resistance Training: A Systematic Review and Meta-analysis.Sports medicine - open · 2026Pooled it
- Serial sarcomere adaptation to eccentric overload training is blunted in ovariectomized rats.Physiological reports · 2026Article
- Solution NMR study of the titin I-band IgI domain I82 shows unusual conformational dynamics.Journal of biomolecular NMR · 2026Article
- Myocardial Recovery With Mechanical Circulatory Support Is Linked to Alternative Splicing and Subcellular Localization of CAMK2D.Circulation · 2026Article
- Human atrial skinned muscle fibers exhibit reduced length-dependent activation but show faster force development kinetics than ventricular muscle.Journal of molecular and cellular cardiology · 2026Article
- Urinary N-terminal titin fragment concentration as a non-invasive biomarker of exercise-induced muscle damage in males and females.European journal of applied physiology · 2026Article
- Central motor commands to human elbow joint muscles during simultaneous changes in their force and length: a preliminary study.Frontiers in physiology · 2026Article
- A "thermodynamic" model of synergistic interaction of human elbow flexor muscles during simultaneous change in their length and force.Frontiers in physiology · 2026Article
- EMG hysteresis patterns in human elbow muscles under simultaneous force and length changes.Scientific reports · 2025Article
- Regional differences in amplitude and spatial homogeneity of muscle activity in the biceps femoris long head.European journal of applied physiology · 2025Article
- Residual force enhancement following hindlimb unloading and exercise prehabilitation.Journal of muscle research and cell motility · 2025Article
- Validation of the energetics of a Huxley muscle-tendon complex model using experimental data obtained from mouse soleus muscle.The Journal of experimental biology · 2025Article
- MyoMed205 Counteracts Titin Hyperphosphorylation and the Expression of Contraction-Regulating Proteins in a Rat Model of HFpEF.Journal of cachexia, sarcopenia and muscle · 2025Article
- Cytoplasmic CaMKIIδ-B prevents myocardial recovery in heart failure.bioRxiv : the preprint server for biology · 2025Article
- Exploring the c.406 C > T variant in TNNI3 gene: pathogenic insights into restrictive cardiomyopathy.BMC medical genomics · 2025Article
- Constitutive Models for Active Skeletal Muscle: Review, Comparison, and Application in a Novel Continuum Shoulder Model.International journal for numerical methods in biomedical engineering · 2025Review
- Using Isometric Squat Strength to Predict Concentric and Eccentric Squat Strength in Young and Older Adults.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2025Article
- Attenuated titin protein expression is associated with advanced stages of ovarian cancer.Molecular therapy. Oncology · 2025Article
- Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease.The Journal of general physiology · 2025Review
- Using 30-s Prone Back Extension Repetition Maximum Test to Predict Concentric and Eccentric 1 Repetition Maximum Squat Strength in Young and Older Adults.Journal of aging research · 2025Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Titin is a filamentous protein spanning the half-sarcomere, with spring-like properties in the I-band region. Various structural, signaling, and mechanical functions have been associated with titin, but not all of these are fully elucidated and accepted in the scientific community. Here, I discuss the primary mechanical functions of titin, including its accepted role in passive force production, stabilization of half-sarcomeres and sarcomeres, and its controversial contribution to residual force enhancement, passive force enhancement, energetics, and work production in shortening muscle. Finally, I provide evidence that titin is a molecular spring whose stiffness changes with muscle activation and actin-myosin-based force production, suggesting a novel model of force production that, aside from actin and myosin, includes titin as a "third contractile" filament. Using this three-filament model of sarcomeres, the stability of (half-) sarcomeres, passive force enhancement, residual force enhancement, and the decrease in metabolic energy during and following eccentric contractions can be explained readily.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.