ArticleJournal of molecular histology2018
The decreased expression of Stat3 and p-Stat3 in preeclampsia-like rat placenta.
Article in Journal of molecular histology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Importance of STAT3 signaling in preeclampsia (Review).International journal of molecular medicine · 2025Review
- Article
- Downregulation of argininosuccinate synthase 1 (ASS1) is associated with hypoxia in placental development.Human cell · 2023Article
- Research progress on the STAT signaling pathway in pregnancy and pregnancy-associated disorders.Frontiers in immunology · 2023Review
- Diagnostic biomolecules and combination therapy for pre-eclampsia.Reproductive biology and endocrinology : RB&E · 2022Review
- Low-Dose Tacrolimus Promotes the Migration and Invasion and Nitric Oxide Production in the Human-Derived First Trimester Extravillous Trophoblast Cells In Vitro.International journal of molecular sciences · 2022Article
- The Efficacy Mechanism of Epigallocatechin Gallate against Pre-Eclampsia based on Network Pharmacology and Molecular Docking.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Bioinformatics analysis combined with clinical sample screening reveals that leptin may be a biomarker of preeclampsia.Frontiers in physiology · 2022Article
- Article
- Interferon γ neutralization reduces blood pressure, uterine artery resistance index, and placental oxidative stress in placental ischemic rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Role of A Novel Angiogenesis FKBPL-CD44 Pathway in Preeclampsia Risk Stratification and Mesenchymal Stem Cell Treatment.The Journal of clinical endocrinology and metabolism · 2021Article
- miR-335 targets CRIM1 to promote the proliferation and inhibit the apoptosis of placental trophoblast cells in preeclamptic rats.American journal of translational research · 2021Article
- Maternal proteomic profiling reveals alterations in lipid metabolism in late-onset fetal growth restriction.Scientific reports · 2020Article
- Down-regulated circPAPPA suppresses the proliferation and invasion of trophoblast cells via the miR-384/STAT3 pathway.Bioscience reports · 2019Article
- Wnt/β-catenin signaling pathway in severe preeclampsia.Journal of molecular histology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to investigate the expression of Stat3 and p-Stat3 in the placenta of a preeclampsia-like rat model induced by Nωnitro-L-arginine methyl ester (L-NAME). Two-to three-month-old (20 males, 40 females) Sprague-Dawley rats were used in this study. After conception was confirmed by vaginal smears, on the thirteenth day of pregnancy, the animals were allocated into two groups: control (0.9% NaCl administered) group and L-NAME (75 mg/kg) group. After the treatment of L-NAME, there was a significant increase in systolic blood pressure (SBP) levels in the L-NAME group (148.5 ± 5.71 mmHg) on day 21 compared to the SBPs in the control group (117.5 ± 4.57 mmHg) (P < 0.001). There was also an increase in total proteinuria on day 21 in the L-NAME group (766.57 ± 17.7 mg/L), when compared to the control group (459.89 ± 20.1 mg/L) (P < 0.001). Moreover, we also found a decrease in fetal numbers and fetal weight in the PE group in comparison to the control group. After the rats were sacrificed, the placentas were obtained from both groups. We found that the L-NAME group exhibited fewer placentas compared with the control group. Furthermore, the immunohistochemistry (IHC) and Western blot results showed that decreased expression of Stat3 and p-Stat3 were detected in the placenta of the preeclampsia-like rat model compared to Stat3 and p-Stat3 in the control group. We found the expression and activation of Stat3 and p-Stat3 were decreased in the placenta of the L-NAME-induced preeclampsia rat model.
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