ArticleArchives of disease in childhood. Fetal and neonatal edition2019
Wide variation in severe neonatal morbidity among very preterm infants in European regions.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Protective effects of different doses of human milk on neonatal necrotizing enterocolitis.Medicine · 2020Pooled it
- Composite neonatal morbidity indicators using hospital discharge data: A systematic review.Paediatric and perinatal epidemiology · 2020Pooled it
- Glomerular Filtration Rate in Former Extreme Low Birth Weight Infants over the Full Pediatric Age Range: A Pooled Analysis.International journal of environmental research and public health · 2020Pooled it
- Five-Minute Apgar Scores and Its Prognostic Value for Mortality and Severe Morbidity in Very Preterm Infants: A Multinational Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026Observational
- Apgar Score Plus Umbilical Artery pH and Adverse Neonatal Outcomes in Very Preterm Infants.JAMA network open · 2026Article
- Early prediction of bronchopulmonary dysplasia: comparison of modelling methods, development and validation studies.Pediatric research · 2026Article
- Associations of language barriers with very preterm children's behavioural and socio-emotional problems across Europe.Pediatric research · 2026Article
- Adding Early Postnatal Parameters of Ventilation to Prognostic Models for Pulmonary Outcome in Very Preterm Infants.Pediatric pulmonology · 2025Article
- Severe Neonatal Morbidity Across Gestational Age: Monitoring Infants at High Risk of Mortality.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Language barriers and mental health problems of preschool children born very preterm in Germany.Developmental medicine and child neurology · 2025Observational
- Comparative analysis of necrotizing enterocolitis in preterm infants born in Japan and born to mothers of Japanese ethnicity in California.Scientific reports · 2025Article
- Neonatal Adverse Outcomes among Hospital Livebirths in Canada: A National Retrospective Study.Neonatology · 2025Article
- Updated Clinical Practice Guidelines in Resuscitation and the Management of Respiratory Distress Syndrome in Extremely Preterm Infants during Two Epochs in Romania: Impact on Outcomes.Journal of clinical medicine · 2024Article
- Article
- Health Insurance and Differences in Infant Mortality Rates in the US.JAMA network open · 2023Article
- Apgar Score and Neurodevelopmental Outcomes at Age 5 Years in Infants Born Extremely Preterm.JAMA network open · 2023Article
- Morbidity and mortality of newborns born to immigrant and nonimmigrant females residing in low-income neighbourhoods.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023Article
- When should a premature neonate (24-35 weeks) be discharged? five-year experience from a single-center neonatal intensive care unit in Türkiye.Turkish journal of medical sciences · 2023Article
- Comparisons of care practices for very preterm infants and their short-term outcomes in two tertiary centers in northwest and south China: A retrospective cohort study.BMC pediatrics · 2022Article
- Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
objectiveTo investigate the variation in severe neonatal morbidity among very preterm (VPT) infants across European regions and whether morbidity rates are higher in regions with low compared with high mortality rates.
designArea-based cohort study of all births before 32 weeks of gestational age.
setting16 regions in 11 European countries in 2011/2012. PATIENTS: Survivors to discharge from neonatal care (n=6422).
main outcome measuresSevere neonatal morbidity was defined as intraventricular haemorrhage grades III and IV, cystic periventricular leukomalacia, surgical necrotizing enterocolitis and retinopathy of prematurity grades ≥3. A secondary outcome included severe bronchopulmonary dysplasia (BPD), data available in 14 regions. Common definitions for neonatal morbidities were established before data abstraction from medical records. Regional severe neonatal morbidity rates were correlated with regional in-hospital mortality rates for live births after adjustment on maternal and neonatal characteristics.
results10.6% of survivors had a severe neonatal morbidity without severe BPD (regional range 6.4%-23.5%) and 13.8% including severe BPD (regional range 10.0%-23.5%). Adjusted inhospital mortality was 13.7% (regional range 8.4%-18.8%). Differences between regions remained significant after consideration of maternal and neonatal characteristics (P<0.001) and severe neonatal morbidity rates were not correlated with mortality rates (P=0.50).
conclusionSevere neonatal morbidity rates for VPT survivors varied widely across European regions and were independent of mortality rates.
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