Evidence map›Paper›PMID 29353249›Full record

ArticleGut2018

Plasma cell-free DNA methylation: a liquid biomarker of hepatic fibrosis.

Buket Yiğit, Marie Boyle, Oğuz Özler, Nihan Erden, Faik Tutucu, Timothy Hardy, Christina Bergmann, Joerg H W Distler, Gupse Adalı, Murat Dayangaç and 3 more

Abstract readLetterValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. The mMolecular therapy : the journal of the American Society of Gene Therapy · 2022
    Article
  6. Epigenetics of alcohol-related liver diseases.JHEP reports : innovation in hepatology · 2022
    Review
  7. Article
  8. Update on genetics and epigenetics in metabolic associated fatty liver disease.Therapeutic advances in endocrinology and metabolism · 2022
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Serum biomarkers for the evaluation of liver fibrosis: The need for better tests.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Buket YiğitDepartment of Gastroenterology and Hepatology, School of Medicine, Koç University, Istanbul, Turkey.
Marie BoyleFaculty of Medical Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
Oğuz ÖzlerDepartment of Gastroenterology and Hepatology, School of Medicine, Koç University, Istanbul, Turkey.
Nihan ErdenDepartment of Gastroenterology and Hepatology, School of Medicine, Koç University, Istanbul, Turkey.
Faik TutucuDepartment of Gastroenterology and Hepatology, School of Medicine, Koç University, Istanbul, Turkey.
Timothy HardyFaculty of Medical Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
Christina BergmannDepartment of Internal Medicine, University of Erlangen-Nuremberg, Erlangen, Germany.
Joerg H W DistlerDepartment of Internal Medicine, University of Erlangen-Nuremberg, Erlangen, Germany.
Gupse AdalıLiver Transplantation Unit, Istanbul Bilim University, Florence Nightingale Hospital, Istanbul, Turkey.
Murat DayangaçLiver Transplantation Unit, Istanbul Bilim University, Florence Nightingale Hospital, Istanbul, Turkey.ORCID 0000-0002-1240-7233
Derek A MannFaculty of Medical Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
Mujdat Zeybel *Department of Gastroenterology and Hepatology, School of Medicine, Koç University, Istanbul, Turkey.
Jelena Mann *Faculty of Medical Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

Funding

Epigenetic Regulation of Alcoholic Liver FibrosisU01AA018663 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KISSELEVA, TATIANA, MANN, DEREK · 2010 to 2019
$3.7M
Medical Research Council MC_PC_13071Medical Research Council MR/K001949/1Medical Research Council MR/L002094/1Medical Research Council MR/L016354/1NIAAA NIH HHS U01 AA018663
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Carcinoma, HepatocellularCell-Free Nucleic AcidsHepatitis B, ChronicLiverLiver CirrhosisNon-alcoholic Fatty Liver DiseasePPAR gammaBiomarkersDisease ProgressionDNA MethylationFemaleHumansLiver NeoplasmsMaleMiddle AgedPromoter Regions, GeneticBiomarkersCell-Free Nucleic AcidsPPAR gammahepatic fibrosishepatitis Bhepatocellular carcinomaliver

Identifiers

PMID29353249
PMCPMC6145292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.