Evidence map›Paper›PMID 29353230›Full record

ArticleMolecular & cellular proteomics : MCP2018

A Model of Dormant-Emergent Metastatic Breast Cancer Progression Enabling Exploration of Biomarker Signatures.

Amanda M Clark, Manu P Kumar, Sarah E Wheeler, Carissa L Young, Raman Venkataramanan, Donna B Stolz, Linda G Griffith, Douglas A Lauffenburger, Alan Wells

Open access · hybridAbstract read
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 55 citations in OpenAlex.

  1. Mechanisms of breast cancer dormancy in bone metastasis.Clinical & experimental metastasis · 2026
    Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Modeling Tumor Cell Dormancy in an Ex Vivo Liver Metastatic Niche.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  11. Article
  12. Review
  13. Engineering Modular 3D Liver Culture MicroenvironmentsAdvanced nanobiomed research · 2022
    Article
  14. Method to Isolate Dormant Cancer Cells from Heterogeneous Populations.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Organs-on-chips: into the next decade.Nature reviews. Drug discovery · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Amanda M ClarkFrom the ‡Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Manu P Kumar§Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Sarah E WheelerFrom the ‡Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Carissa L Young§Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Raman VenkataramananFrom the ‡Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Donna B StolzFrom the ‡Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Linda G Griffith§Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Douglas A Lauffenburger§Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Alan WellsFrom the ‡Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania; wellsa@upmc.edu.
Massachusetts Institute of Technology · USUniversity of Pittsburgh · USUPMC Hillman Cancer Center · US

Funding

Probing the Role of the Tumor Microenvironment on Mechanistic Biomarkers for Chemotherapeutic ResistanceUH3TR000496 · NCATS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRIFFITH, LINDA G · 2014 to 2016
$3.5M
All-Human Microphysical Model of Metastasis TherapyUH2TR000496 · NCATS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRIFFITH, LINDA G · 2012 to 2013
$2.3M
Molecular Regulation of Breast Cancer ProgressionI01BX003368 · VA · VETERANS HEALTH ADMINISTRATION · PI WELLS, ALAN · 2016 to 2023
–
BLRD VA I01 BX003368NCATS NIH HHS UH2 TR000496NCATS NIH HHS UH3 TR000496
6 · The paper itself

Abstract

Breast cancer mortality predominantly results from dormant micrometastases that emerge as fatal outgrowths years after initial diagnosis. In order to gain insights concerning factors associated with emergence of liver metastases, we recreated spontaneous dormancy in an all-human

Indexed as

Biomarkers, TumorBreast NeoplasmsCell Line, TumorFemaleHumansLiverBiomarkers, Tumor

Identifiers

PMID29353230
PMCPMC5880110
OpenAlexW2789979251

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.