Evidence map›Paper›PMID 29353210›Full record

ArticleVirology2018

VPg unlinkase/TDP2 in cardiovirus infected cells: Re-localization and proteolytic cleavage.

Sonia Maciejewski, Wendy Ullmer, Bert L Semler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors.Bioorganic & medicinal chemistry letters · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sonia MaciejewskiDepartment of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697, USA.
Wendy UllmerDepartment of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697, USA.
Bert L SemlerDepartment of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697, USA. Electronic address: blsemler@uci.edu.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Virus-host interactions: a multi-scale training programT32AI007319 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI SEMLER, BERT L, SHI, YONGSHENG · 1988 to 2024
$2.4M
Role of host cell protein TDP2 as VPg unlinkase during picornavirus replicationR01AI110782 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI SEMLER, BERT L · 2014 to 2018
$1.8M
NCI NIH HHS P30 CA062203NIAID NIH HHS R01 AI110782NIAID NIH HHS T32 AI007319
6 · The paper itself

Abstract

Cardioviruses cause diseases in many animals including, in rare cases, humans. Although they share common features with all picornaviruses, cardioviruses have unique properties that distinguish them from other family members, including enteroviruses. One feature shared by all picornaviruses is the covalent attachment of VPg to the 5' end of genomic RNA via a phosphotyrosyl linkage. For enteroviruses, this linkage is cleaved by a host cell protein, TDP2. Since TDP2 is divergently required during enterovirus infections, we determined if TDP2 is necessary during infection by the prototype cardiovirus, EMCV. We found that EMCV yields are reduced in the absence of TDP2. We observed a decrease in viral protein accumulation and viral RNA replication in the absence of TDP2. In contrast to enterovirus infections, we found that TDP2 is modified at peak times of EMCV infection. This finding suggests a unique mechanism for cardioviruses to regulate TDP2 activity during infection.

Indexed as

AnimalsCardiovirusCardiovirus InfectionsCell NucleusCytoplasmDNA-Binding ProteinsFibroblastsHeLa CellsHost-Pathogen InteractionsHumansMiceMice, KnockoutNuclear ProteinsPhosphoric Diester HydrolasesProtein TransportProteolysisDNA-Binding ProteinsNuclear ProteinsPhosphoric Diester HydrolasesRNA, ViralTDP2 protein, humanTDP2 protein, mouseTranscription FactorsTumor Necrosis Factor Receptor-Associated Peptides and ProteinsViral Proteins5′ tyrosyl-DNA phosphodiesterase 2CardiovirusEMCVEncephalomyocarditis virusPicornavirusTDP2Virus-host interactions

Identifiers

PMID29353210
PMCPMC5826889

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.