ArticleCortex; a journal devoted to the study of the nervous system and behavior2018
Tau-PET imaging with [18F]AV-1451 in primary progressive apraxia of speech.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 50 citations in OpenAlex.
- Distinct 11C-ER176 PET Neuroinflammatory Profiles and Tau Colocalization in Progressive Apraxia of Speech With and Without Parkinson-plus Syndrome.Clinical nuclear medicine · 2025Article
- Unveiling the enigmatic: Primary progressive apraxia of speech - A case report.Clinical parkinsonism & related disorders · 2025Article
- Microscopy assessment of a fluorescence [Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Multimodal cross-examination of progressive apraxia of speech by diffusion tensor imaging-based tractography and Tau-PET scans.Human brain mapping · 2024Article
- Longitudinal flortaucipir, metabolism and volume differ between phonetic and prosodic speech apraxia.Brain : a journal of neurology · 2024Article
- 25-year neuroimaging research on spoken language processing: a bibliometric analysis.Frontiers in human neuroscience · 2024Article
- A review of the flortaucipir literature for positron emission tomography imaging of tau neurofibrillary tangles.Brain communications · 2024Review
- Longitudinal characterization of patients with progressive apraxia of speech without clearly predominant phonetic or prosodic speech features.Brain and language · 2023Article
- Three-Dimensional Speech Profiles in Stroke Aphasia and Apraxia of Speech.American journal of speech-language pathology · 2023Article
- An Update on Apraxia of Speech.Current neurology and neuroscience reports · 2023Review
- Amyloid and Tau PET Positivity in Progressive Agrammatic Aphasia and Apraxia of Speech.Journal of Alzheimer's disease : JAD · 2023Article
- Optimum Differentiation of Frontotemporal Lobar Degeneration from Alzheimer Disease Achieved with Cross-Sectional Tau Positron Emission Tomography.Annals of neurology · 2022Article
- Neuropsychological Profiles of Patients with Progressive Apraxia of Speech and Aphasia.Journal of the International Neuropsychological Society : JINS · 2022Article
- Assessing Change in Communication Limitations in Primary Progressive Apraxia of Speech and Aphasia: A 1-Year Follow-Up Study.American journal of speech-language pathology · 2021Article
- Comparing ATN-T designation by tau PET visual reads, tau PET quantification, and CSF PTau181 across three cohorts.European journal of nuclear medicine and molecular imaging · 2021Article
- Speech Metrics and Samples That Differentiate Between Nonfluent/Agrammatic and Logopenic Variants of Primary Progressive Aphasia.Journal of speech, language, and hearing research : JSLHR · 2021Article
- Article
- Modelling speech motor programming and apraxia of speech in the DIVA/GODIVA neurocomputational framework.Aphasiology · 2021Article
- Diagnostic Assessment in Primary Progressive Aphasia: An Illustrative Case Example.American journal of speech-language pathology · 2020Article
- Communication Limitations in Patients With Progressive Apraxia of Speech and Aphasia.American journal of speech-language pathology · 2020Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Apraxia of speech is a motor speech disorder characterized by combinations of slow speaking rate, abnormal prosody, distorted sound substitutions, and trial-and-error articulatory movements. Apraxia of speech is due to abnormal planning and/or programming of speech production. It is referred to as primary progressive apraxia of speech (PPAOS) when it is the only symptom of a neurodegenerative condition. Past reports suggest an association of PPAOS with primary 4-repeat (4R) tau (e.g., progressive supranuclear palsy, corticobasal degeneration), rather than amyloid, pathology. The goal of the current study was to investigate the distribution of tau tracer uptake using [18F]AV-1451 positron emission tomography (PET) imaging in patients with PPAOS. Fourteen PPAOS patients underwent [18F]AV-1451 PET (tau-PET) imaging, [C11] Pittsburgh Compound B (PiB) PET and structural MRI and were matched 3:1 by age and sex to 42 cognitively normal controls. Tau-PET uptake was assessed at the region-of-interest (ROI) level and at the voxel-level. The PPAOS group (n = 14) showed increased tau-PET uptake in the precentral gyrus, supplementary motor area and Broca's area compared to controls. To examine whether tau deposition in Broca's area was related to the presence of aphasia, we examined a subgroup of the PPAOS patients who had predominant apraxia of speech, with concomitant aphasia (PPAOSa; n = 7). The PPAOSa patients showed tau-PET uptake in the same regions as the whole group. However, the remaining seven patients who did not have aphasia showed uptake only in superior premotor and precentral cortices, with no uptake observed in Broca's area. This cross-sectional study demonstrates that elevated tau tracer uptake is observed using [18F]AV-1451 in PPAOS. Further, it appears that [18F]AV-1451 is sensitive to the regional distribution of tau deposition in different stages of PPAOS, given the relationship between tau signal in Broca's area and the presence of aphasia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.