Evidence map›Paper›PMID 29352849›Full record

ArticleClinical and experimental rheumatology

Impact of vasculitis on employment and income.

Lillian Barra, Renée L Borchin, Cristina Burroughs, George C Casey, Carol A McAlear, Antoine G Sreih, Kalen Young, Peter A Merkel, Christian Pagnoux, Vasculitis Clinical Research Consortium and the Vasculitis Patient-Powered Research Network.

Abstract read
In one paragraph

Article in Clinical and experimental rheumatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Characterizing the Cellular Constituents of Proximal Airway Disease in Granulomatosis With Polyangiitis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Large-vessel vasculitis.Nature reviews. Disease primers · 2022
    Review
  9. Article
  10. Article
  11. A scoping Review of tools used to assess patient Complexity in rheumatic disease.Health expectations : an international journal of public participation in health care and health policy · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Lillian BarraDivision of Rheumatology, Western University, London, Ontario, Canada.
Renée L BorchinHealth Informatics Institute, University of South Florida, Tampa, FL, USA.
Cristina BurroughsHealth Informatics Institute, University of South Florida, Tampa, FL, USA.
George C CaseyVasculitis Foundation, Kansas City, MO, USA.
Carol A McAlearVasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA.
Antoine G SreihVasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA.
Kalen YoungVasculitis Foundation, Kansas City, MO, USA.
Peter A MerkelVasculitis Center, Division of Rheumatology; and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.
Christian PagnouxVasculitis clinic, Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Ontario, Canada. cpagnoux@mtsinai.on.ca.
Vasculitis Clinical Research Consortium and the Vasculitis Patient-Powered Research Network.
University of Pennsylvania · USUniversity of South Florida · USVasculitis Foundation · USMount Sinai Hospital · CAWestern University · CA

Funding

Rare Diseases Data Management and Coordinating CenterU01TR001263 · NCATS · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2014 to 2018
$28.1M
VCRC-VF FellowshipU54AR057319 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MERKEL, PETER A · 2009 to 2020
$12.5M
VASCULITIS CLINICAL RESEARCH NETWORK (VCRN): RARE DISEASEU54RR019497 · NCRR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MERKEL, PETER A · 2003 to 2008
$6.1M
NCATS NIH HHS U01 TR001263NCRR NIH HHS U54 RR019497NIAMS NIH HHS U54 AR057319
6 · The paper itself

Abstract

objectivesWork disability associated with rheumatic diseases accounts for a substantial financial burden. However, few studies have investigated disability among patients with vasculitis. The purpose of this study was to examine the impact of vasculitis on patient employment and income.

methodsPatients enrolled in the Vasculitis Clinical Research Consortium (VCRC) Patient Contact Registry, living in the USA or Canada, and followed for >1 year post-diagnosis, participated in an online survey-based study.

results421 patients with different systemic vasculitides completed the survey between June and December 2015. The majority of patients were female (70%) and Caucasian (90%); granulomatosis with polyangiitis (GPA) was the most common type of vasculitis (49%), and the mean age at the time of diagnosis was 53 years. At the time of their diagnosis of vasculitis 76% of patients were working a paid job, 6% were retired, and 2% were on disability. Over the course of their disease, and with a mean follow-up of 8±6.4 years post-diagnosis, 26% of participants became permanently work disabled or had to retire early due to vasculitis. Variables that were independently associated with permanent work disability included work physicality, less supportive work environment, and symptoms such as respiratory disease, pain, and cognitive impairment. Overall, patients reported a mean productivity loss of 6.9% and income was reduced by a median of 45%.

conclusionsDue to their vasculitis, patients frequently suffer substantial limitations in work and productivity, and personal income loss.

Indexed as

Cost of IllnessEfficiencyAdultAgedCanadaEmploymentFemaleHumansIncomeMaleMiddle AgedPersons with DisabilitiesSurveys and QuestionnairesSystemic VasculitisUnited StatesVasculitis

Identifiers

PMID29352849
PMCPMC6003628
OpenAlexW2990082232

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.