Evidence map›Paper›PMID 29352633›Full record

ReviewJournal of autoimmunity2018

Current concerns and perspectives on Zika virus co-infection with arboviruses and HIV.

Hussin A Rothan, Mehdi R M Bidokhti, Siddappa N Byrareddy

Abstract readReview
In one paragraph

Review in Journal of autoimmunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

  1. Pooled it
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  11. Trends in ELISA-Based Flavivirus IgG Serosurveys: A Systematic Review.Tropical medicine and infectious disease · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Hussin A RothanDepartment of Human Biology, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia. Electronic address: hussinrothan@imu.edu.my.
Mehdi R M BidokhtiDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Centre (UNMC), Omaha, NE 68198-5800, USA. Electronic address: mehdi.bidokhti@unmc.edu.
Siddappa N ByrareddyDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Centre (UNMC), Omaha, NE 68198-5800, USA. Electronic address: sid.byrareddy@unmc.edu.
Nebraska Medical Center · USIMU University · MY

Funding

Role of HIV Env glycosylation in mucosal transmissionR01AI113883 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BYRAREDDY, SIDDAPPA N · 2014 to 2018
$3.9M
Transmitted/Founder SHIV macaque modelR21AI114415 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BYRAREDDY, SIDDAPPA N · 2015 to 2016
$414k
Targeting gut-brain axis to eliminate CNS reservoirsR21MH113455 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BYRAREDDY, SIDDAPPA N · 2017 to 2018
$414k
NIAID NIH HHS R01 AI113883NIAID NIH HHS R21 AI114415NIMH NIH HHS R21 MH113455
6 · The paper itself

Abstract

Dissemination of vector-borne viruses, such as Zika virus (ZIKV), in tropical and sub-tropical regions has a complicated impact on the immunopathogenesis of other endemic viruses such as dengue virus (DENV), chikungunya virus (CHIKV) and human immunodeficiency virus (HIV). The consequences of the possible co-infections with these viruses have specifically shown significant impact on the treatment and vaccination strategies. ZIKV is a mosquito-borne flavivirus from African and Asian lineages that causes neurological complications in infected humans. Many of DENV and CHIKV endemic regions have been experiencing outbreaks of ZIKV infection. Intriguingly, the mosquitoes, Aedes Aegypti and Aedes Albopictus, can simultaneously transmit all the combinations of ZIKV, DENV, and CHIKV to the humans. The co-circulation of these viruses leads to a complicated immune response due to the pre-existence or co-existence of ZIKV infection with DENV and CHIKV infections. The non-vector transmission of ZIKV, especially, via sexual intercourse and placenta represents an additional burden that may hander the treatment strategies of other sexually transmitted diseases such as HIV. Collectively, ZIKV co-circulation and co-infection with other viruses have inevitable impact on the host immune response, diagnosis techniques, and vaccine development strategies for the control of these co-infections.

Indexed as

AedesAnimalsArbovirusesChikungunya FeverCoinfectionDisease VectorsEndemic DiseasesHIVHIV InfectionsHumansInfection ControlVaccinationViral VaccinesZika VirusZika Virus InfectionViral VaccinesChikungunyaCo-circulationCo-infectionDengueFlavivirusHIVVaccinationZika virus

Identifiers

PMID29352633
PMCPMC5902419
OpenAlexW2783278008

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.