The promise and challenges of drug repurposing in psychiatry.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

1. Effect of n-3 polyunsaturated fatty acids on the treatment of schizophrenia: an updated systematic review and meta-analysis.BMC psychiatry · 2025
   Pooled it
2. Minocycline as Treatment for Psychiatric and Neurological Conditions: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2023
   Pooled it
3. Efficacy and target engagement of dopamine agonist pramipexole for anhedonic depression: a randomized placebo-controlled trial.Nature medicine · 2026
   Trial
4. The cell-type specific interaction based drug repurposing for psychiatric disorders.Translational psychiatry · 2026
   Article
5. From betel nuts to Cobenfy: how an ancient recreational drug gave rise to a new class of schizophrenia medications.CNS spectrums · 2025
   Review
6. Efficacy and Safety of Antidiabetic Agents for Major Depressive Disorder and Bipolar Depression: A Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Trials.Journal of clinical medicine · 2024
   Article
7. Add-on pramipexole for anhedonic depression: study protocol for a randomised controlled trial and open-label follow-up in Lund, Sweden.BMJ open · 2023
   Article
8. Major depressive disorder.Nature reviews. Disease primers · 2023
   Review
9. The pharmacological bases for repurposing statins in depression: a review of mechanistic studies.Translational psychiatry · 2023
   Review
10. Advancements in Drug Repurposing: Examples in Psychiatric Medications.International journal of molecular sciences · 2023
    Article
11. Augmentation Therapies as Treatments for Coexisting Somatic Problems in Schizophrenia-A Systematic Review.Journal of clinical medicine · 2023
    Review
12. Efficacy and Safety of Clonidine in the Treatment of Acute Mania in Bipolar Disorder: A Systematic Review.Brain sciences · 2023
    Review
13. Genetics-informed precision treatment formulation in schizophrenia and bipolar disorder.American journal of human genetics · 2022
    Article
14. Drug repositioning in drug discovery of T2DM and repositioning potential of antidiabetic agents.Computational and structural biotechnology journal · 2022
    Review
15. Genetics of substance use disorders: a review.Psychological medicine · 2021
    Article
16. "Novel Psychopharmacology for Depressive Disorders".Advances in experimental medicine and biology · 2021
    Review
17. Transcriptome-wide association analysis offers novel opportunities for clinical translation of genetic discoveries on mental disorders.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2020
    Article
18. The role of shared decision-making in improving adherence to pharmacological treatments in patients with schizophrenia: a clinical review.Annals of general psychiatry · 2020
    Review
19. On-Label or Off-Label? Overcoming Regulatory and Financial Barriers to Bring Repurposed Medicines to Cancer Patients.Frontiers in pharmacology · 2019
    Article
20. The Role of Precision Medicine in Child Psychiatry: What Can We Expect and When?Journal of the American Academy of Child and Adolescent Psychiatry · 2018
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.