ArticleNeuroinformatics2018
A Spatial Registration Toolbox for Structural MR Imaging of the Aging Brain.
Article in Neuroinformatics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 13 citations in OpenAlex.
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- aXonica: A support package for MRI based Neuroimaging.Biotechnology notes (Amsterdam, Netherlands) · 2024Article
- Confounds in neuroimaging: A clear case of sex as a confound in brain-based prediction.Frontiers in neurology · 2022Article
- Multi-atlas image registration of clinical data with automated quality assessment using ventricle segmentation.Medical image analysis · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
During aging the brain undergoes a series of structural changes, in size, shape as well as tissue composition. In particular, cortical atrophy and ventricular enlargement are often present in the brain of elderly individuals. This poses serious challenges in the spatial registration of structural MR images. In this study, we addressed this open issue by proposing an enhanced framework for MR registration and segmentation. Our solution was compared with other approaches based on the tools available in SPM12, a widely used software package. Performance of the different methods was assessed on 229 T1-weighted images collected in healthy individuals, with age ranging between 55 and 90 years old. Our method showed a consistent improvement as compared to other solutions, especially for subjects with enlarged lateral ventricles. It also provided a superior inter-subject alignment in cortical regions, with the most marked improvement in the frontal lobe. We conclude that our method is a valid alternative to standard approaches based on SPM12, and is particularly suitable for the processing of structural MR images of brains with cortical atrophy and ventricular enlargement. The method is integrated in our software toolbox MRTool, which is freely available to the scientific community.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.