ArticleScientific reports2018
Effect of in vitro storage duration on measured mechanical properties of brain tissue.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 29 citations in OpenAlex.
- A Comprehensive Analysis of Inconsistencies in the Brain's Conventional Ex Vivo Mechanical Experiments.Annals of biomedical engineering · 2025Review
- The use of brain tissue mechanics for time since death estimations.International journal of legal medicine · 2023Article
- Structural Anisotropy vs. Mechanical Anisotropy: The Contribution of Axonal Fibers to the Material Properties of Brain White Matter.Annals of biomedical engineering · 2021Article
- Effect of Soybean Meal Substitution by Raw Chickpea Seeds on Thermal Properties and Fatty Acid Composition of Subcutaneous Fat Tissue of Broiler Chickens.Animals : an open access journal from MDPI · 2020Article
- Mechanical regulation of oligodendrocyte biology.Neuroscience letters · 2020Review
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accurate characterization of the mechanical properties of brain tissue is essential for understanding the mechanisms of traumatic brain injuries and developing protective gears or facilities. However, how storage conditions might affect the mechanical properties of brain tissue remains unclear. The objective of this study is to investigate the effect of in vitro storage duration on the mechanical performance of brain tissue since measurements are usually carried out in vitro. Differential Scanning Calorimetry (DSC) measurements and uniaxial compression mechanical experiments are carried out. The results indicate that, for brain tissue stored at 1 °C without any liquid medium, the bio-molecular interactions and the mechanical strength of both white and grey matter deteriorate with prolonged storage duration. Transmission Electron Microscopy (TEM) results reveal the degeneration of myelin sheaths and the vacuolization of cristae with prolonged storage duration, suggesting that the in vitro storage duration should be carefully controlled. The findings from this study might facilitate the development of guidelines and standards for the in vitro storage of brain tissue.
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