ArticleScientific reports2018
Short Tandem Repeat analysis after Whole Genome Amplification of single B-lymphoblastoid cells.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Novel and High-Throughput Method of Isolating Single Fetal Cells Using FACS for NIPT.Prenatal diagnosis · 2026Article
- DNA forensics at forty: the way forward.International journal of legal medicine · 2025Review
- Automated and Enclosed Three-Dimensional Biofabrication System for Mesenchymal Stem Cell Culture to Enhance Diabetic Wound Healing.Biomaterials research · 2025Article
- New Perspectives for Whole Genome Amplification in Forensic STR Analysis.International journal of molecular sciences · 2022Review
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- Genomic anatomy of male-specific microchromosomes in a gynogenetic fish.PLoS genetics · 2021Article
- Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse.Nature medicine · 2019Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To allow multiple genetic analyses on a single cell, whole genome amplification (WGA) is required. Unfortunately, studies comparing different WGA methods for downstream human identification Short Tandem Repeat (STR) analysis remain absent. Therefore, the aim of this work was to assess the performance of four commercially available WGA kits for downstream human identification STR profiling on a B-lymphoblastoid cell line. The performance was assessed using an input of one or three micromanipulated cells. REPLI-g showed a very low dropout rate, as it was the only WGA method in this study that could provide a complete STR profile in some of its samples. Although Ampli1, DOPlify and PicoPLEX did not detect all selected STR markers, they seem suitable for genetic identification in single-cell applications.
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