ArticleScientific reports2018
Abnormal Speech Motor Control in Individuals with 16p11.2 Deletions.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- A randomised controlled trial investigating the causal role of the medial prefrontal cortex in mediating self-agency during speech monitoring and reality monitoring.Scientific reports · 2024Trial
- Auditory processing and communication in autism: exploring verbal abilities and vocal affective cues.Frontiers in psychiatry · 2026Article
- Vocal and articulatory speech control deficits in individuals with post-stroke aphasia.Scientific reports · 2025Article
- The pleiotropic spectrum of proximal 16p11.2 CNVs.American journal of human genetics · 2024Review
- Mirrors and toothaches: commonplace manipulations of non-auditory feedback availability change perceived speech intelligibility.Frontiers in human neuroscience · 2024Article
- Speech sensorimotor relationships in francophone preschoolers and adults: Adaptation to real-time auditory feedback perturbations.PloS one · 2024Article
- Beyond words: an investigation of fine motor skills and the verbal communication spectrum in autism.Frontiers in psychiatry · 2024Article
- Health supervision for children and adolescents with 16p11.2 deletion syndrome.Cold Spring Harbor molecular case studies · 2023Article
- A Gene-Based Algorithm for Identifying Factors That May Affect a Speaker's Voice.Entropy (Basel, Switzerland) · 2023Article
- Associations between rapid auditory processing of speech sounds and specific verbal communication skills in autism.Frontiers in psychology · 2023Article
- Clinical Implications of Chromosome 16 Copy Number Variation.Molecular syndromology · 2022Article
- Identifying distinct latent classes of pitch-shift response consistency: Evidence from manipulating the predictability of shift direction.Frontiers in psychology · 2022Article
- Pediatric Responses to Fundamental and Formant Frequency Altered Auditory Feedback: A Scoping Review.Frontiers in human neuroscience · 2022Article
- Quantitatively characterizing reflexive responses to pitch perturbations.Frontiers in human neuroscience · 2022Article
- A Causal Role of the Cerebellum in Auditory Feedback Control of Vocal Production.Cerebellum (London, England) · 2021Article
- Delayed motor learning in a 16p11.2 deletion mouse model of autism is rescued by locus coeruleus activation.Nature neuroscience · 2021Article
- Three case reports of patients indicating the diversity of molecular and clinical features of 16p11.2 microdeletion anomaly.BMC medical genomics · 2021Article
- Speech compensation responses and sensorimotor adaptation to formant feedback perturbations.The Journal of the Acoustical Society of America · 2021Article
- 16p11.2 Copy Number Variations and Neurodevelopmental Disorders.Trends in neurosciences · 2020Review
- Auditory-Motor Perturbations of Voice Fundamental Frequency: Feedback Delay and Amplification.Journal of speech, language, and hearing research : JSLHR · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Speech and motor deficits are highly prevalent (>70%) in individuals with the 600 kb BP4-BP5 16p11.2 deletion; however, the mechanisms that drive these deficits are unclear, limiting our ability to target interventions and advance treatment. This study examined fundamental aspects of speech motor control in participants with the 16p11.2 deletion. To assess capacity for control of voice, we examined how accurately and quickly subjects changed the pitch of their voice within a trial to correct for a transient perturbation of the pitch of their auditory feedback. When compared to controls, 16p11.2 deletion carriers show an over-exaggerated pitch compensation response to unpredictable mid-vocalization pitch perturbations. We also examined sensorimotor adaptation of speech by assessing how subjects learned to adapt their sustained productions of formants (speech spectral peak frequencies important for vowel identity), in response to consistent changes in their auditory feedback during vowel production. Deletion carriers show reduced sensorimotor adaptation to sustained vowel identity changes in auditory feedback. These results together suggest that 16p11.2 deletion carriers have fundamental impairments in the basic mechanisms of speech motor control and these impairments may partially explain the deficits in speech and language in these individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.