ArticleScientific reports2018
Structural Covariance of Gray Matter Volume in HIV Vertically Infected Adolescents.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Safety and efficacy outcomes after intranasal administration of neural stem cells in cerebral palsy: a randomized phase 1/2 controlled trial.Stem cell research & therapy · 2023Trial
- Divergent structural and functional brain alterations in HIV-infected patients: a multimodal meta-analysis.Frontiers in neurology · 2025Review
- Network biomarkers of Alzheimer's disease risk derived from joint volume and texture covariance patterns in mouse models.PloS one · 2025Article
- Neuroimaging advances in neurocognitive disorders among HIV-infected individuals.Frontiers in neurology · 2025Review
- Relationship between brain structural network integrity and emotional symptoms in youth with perinatally-acquired HIV.Brain, behavior, and immunity · 2024Article
- Reduced white matter maturation in the central auditory system of children living with HIV.Frontiers in neuroimaging · 2024Article
- A longitudinal study of the brain structure network changes in HIV patients with ANI: combined VBM with SCN.Frontiers in neurology · 2024Article
- Whole-brain MR spectroscopic imaging reveals regional metabolite abnormalities in perinatally HIV infected young adults.Frontiers in neuroscience · 2023Article
- Maternal ART throughout gestation prevents caudate volume reductions in neonates who are HIV exposed but uninfected.Frontiers in neuroscience · 2023Article
- Abnormal cortical thickness and structural covariance networks in systemic lupus erythematosus patients without major neuropsychiatric manifestations.Arthritis research & therapy · 2022Article
- Central Nervous System Impact of Perinatally Acquired HIV in Adolescents and Adults: an Update.Current HIV/AIDS reports · 2022Review
- Altered gray matter structural covariance networks in drug-naïve and treated early HIV-infected individuals.Frontiers in neurology · 2022Article
- Longitudinal trajectories of brain volume in combined antiretroviral therapy treated and untreated simian immunodeficiency virus-infected rhesus macaques.AIDS (London, England) · 2021Article
- Effects of perinatal HIV-infection on the cortical thickness and subcortical gray matter volumes in young adulthood.Medicine · 2021Article
- Hypertension With High Homocysteine Is Associated With Default Network Gray Matter Loss.Frontiers in neurology · 2021Article
- HIV-Associated Structural and Functional Brain Alterations in Homosexual Males.Frontiers in neurology · 2021Article
- Gout Is Not Just Arthritis: Abnormal Cortical Thickness and Structural Covariance Networks in Gout.Frontiers in neurology · 2021Article
- A longitudinal study of brain volume changes in rhesus macaque model infected with SIV.Journal of neurovirology · 2020Article
- Neurocognitive impairment and gray matter volume reduction in HIV-infected patients.Journal of neurovirology · 2020Article
- Brain morphometric differences in youth with and without perinatally-acquired HIV: A cross-sectional study.NeuroImage. Clinical · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human immunodeficiency virus (HIV) infection significantly affect neurodevelopmental and behavioral outcomes. We investigated whether alterations of gray matter organization and structural covariance networks with vertical HIV infection adolescents exist, by using the GAT toolbox. MRI data were analysed from 25 HIV vertically infected adolescents and 33 HIV-exposed-uninfected control participants. The gray matter volume (GMV) was calculated, and structural brain networks were reconstructed from gray matter co-variance. Gray matter losses were pronounced in anterior cingulate cortex (ACC), right pallidum, right occipital lobe, inferior parietal lobe, and bilateral cerebellum crus. The global brain network measures were not significantly different between the groups; however, the nodal alterations were most pronounced in frontal, temporal, basal ganglia, cerebellum, and temporal lobes. Brain hubs in the HIV-infected subjects increased in number and tended to shift to sensorimotor and temporal areas. In the HIV-infected subjects, decreased GMVs in ACC and bilateral cerebellum were related to lower Mini-Mental State Examination scores; the CD4 counts were positively related to the GMVs in ACC and sensorimotor areas. These findings suggest that focally reduced gray matter, disrupted nodal profiles of structural wirings, and a shift in hub distribution may represent neuroanatomical biomarkers of HIV infection on the developing brain.
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