Evidence map›Paper›PMID 29352104›Full record

ArticleThe Journal of biological chemistry2018

A PH-like domain of the Rab12 guanine nucleotide exchange factor DENND3 binds actin and is required for autophagy.

Jie Xu, Guennadi Kozlov, Peter S McPherson, Kalle Gehring

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Rab12 is a regulator of mitophagy and mitochondrial homeostasis.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Organization of Presynaptic Autophagy-Related Processes.Frontiers in synaptic neuroscience · 2022
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. A new actin-binding domain glues autophagy together.The Journal of biological chemistry · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jie XuFrom the Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada and.
Guennadi Kozlovthe Department of Biochemistry, McGill Centre for Structural Biology, McGill University, Montreal, Quebec H3G 0B1, Canada.
Peter S McPhersonFrom the Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada and.
Kalle Gehringthe Department of Biochemistry, McGill Centre for Structural Biology, McGill University, Montreal, Quebec H3G 0B1, Canada kalle.gehring@mcgill.ca.
McGill University · CAMontreal Neurological Institute and Hospital · CA

Funding

ZINC FINGER-DNA COMPLEXP41RR001646 · NCRR · CORNELL UNIVERSITY ITHACA · PI CINGOLANI, GINO · 1985 to 2011
$23.8M
CIHR MOP-14219NCRR NIH HHS P41 RR001646NIGMS NIH HHS DMR-0225180
6 · The paper itself

Abstract

Rab GTPases are key regulators of membrane trafficking, and many are activated by guanine nucleotide exchange factors bearing a

Indexed as

AutophagyActinsBlood ProteinsCrystallography, X-RayGuanine Nucleotide Exchange FactorsHEK293 CellsHumansPhosphoproteinsPhosphorylationProtein BindingProtein ConformationProtein Domainsrab GTP-Binding ProteinsActinsBlood ProteinsDENND3 protein, humanGuanine Nucleotide Exchange FactorsPhosphoproteinsplatelet protein P47Rab12 protein, humanrab GTP-Binding ProteinsactinautophagyDENND3DENN domainGTPaseguanine-nucleotide exchange factor (GEF)intramolecular interactionPH domainPHenn domainRabRab12structural biologystructure-function

Identifiers

PMID29352104
PMCPMC5868273
OpenAlexW2784640691

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.