SynthesisNeurology2018
Smoking and Parkinson disease: Evidence for gene-by-smoking interactions.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Trial
- Dual-Risk axis:Journal of Parkinson's disease · 2026Article
- Preventing Parkinson's disease in the context of movement disorders: a narrative review of current evidence and future directions.Neurological research and practice · 2026Review
- Dynamic Smoking Patterns and Risk of Parkinson Disease and All-Cause Mortality: A Competing Risk Analysis Approach.Neurology · 2026Article
- Proposed mechanisms of neuroprotection for nicotine in Parkinson's disease.Journal of Parkinson's disease · 2025Review
- Brain Cytochrome P450: Navigating Neurological Health and Metabolic Regulation.Journal of xenobiotics · 2025Review
- The association between cigarette smoking and dementia with Lewy bodies.Parkinsonism & related disorders · 2024Article
- The combined effect of lifestyle factors and polygenic scores on age at onset in Parkinson's disease.Scientific reports · 2024Article
- The combined effect of lifestyle factors and polygenic scores on age at onset in Parkinson's disease.medRxiv : the preprint server for health sciences · 2023Article
- The burden of Parkinson's disease in the Middle East and North Africa region, 1990-2019: results from the global burden of disease study 2019.BMC public health · 2023Article
- Effect Modification between Genes and Environment and Parkinson's Disease Risk.Annals of neurology · 2022Review
- Life style and Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- The protective role of cigarette smoking against Parkinson's disease via moderation of the interaction between iron deposition in the nigrostriatal pathway and clinical symptoms.Quantitative imaging in medicine and surgery · 2022Article
- Mendelian Randomisation Study of Smoking, Alcohol, and Coffee Drinking in Relation to Parkinson's Disease.Journal of Parkinson's disease · 2022Article
- Letter to the Editor regarding Wang Y, Liu Y, Yan H. 2020. Effect of long-term particulate matter exposure on Parkinson's risk.Environmental geochemistry and health · 2021Article
- Alterations of Cytochrome P450s and UDP-Glucuronosyltransferases in Brain Under Diseases and Their Clinical Significances.Frontiers in pharmacology · 2021Review
- Association between vitiligo and smoking: A nationwide population-based study in Korea.Scientific reports · 2020Article
- Role of Alcohol Drinking in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis.International journal of molecular sciences · 2020Review
- Metal Exposure and SNCA rs356219 Polymorphism Associated With Parkinson Disease and Parkinsonism.Frontiers in neurology · 2020Article
- VGLUT2 rs2290045 genotype moderates environmental sensitivity to alcohol-related problems in three samples of youths.European child & adolescent psychiatry · 2019Article
Corrections and comments
- Commented on by
Authors and funding
8 authors at 1 institution in 1 country.
Pei-Chen LeeFrom the Department of Health Care Management (P.-C.L.), College of Health Technology, National Taipei University of Nursing and Health Sciences, Taiwan; Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (I.A.), INSERM, UVSQ, Institut Pasteur, Université Paris-Saclay, Villejuif; Assistance-Publique-Hôpitaux de Paris (M.-A.L.), Hôpital Européen Georges Pompidou, Biochimie, Pharmacogénétique et Oncologie Moléculaire; INSERM UMR-S 1147 (C.M.), CRB EPIGENETEC, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Departments of Epidemiology (K.C.P., B.R.) and Environmental Health (J.M.B., B.R.), Fielding School of Public Health, and Department of Neurology (J.M.B., B.R.), Geffen School of Medicine, University of California at Los Angeles; and Université Paris-Saclay (A.E.), Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.
Ismaïl AhmedFrom the Department of Health Care Management (P.-C.L.), College of Health Technology, National Taipei University of Nursing and Health Sciences, Taiwan; Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (I.A.), INSERM, UVSQ, Institut Pasteur, Université Paris-Saclay, Villejuif; Assistance-Publique-Hôpitaux de Paris (M.-A.L.), Hôpital Européen Georges Pompidou, Biochimie, Pharmacogénétique et Oncologie Moléculaire; INSERM UMR-S 1147 (C.M.), CRB EPIGENETEC, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Departments of Epidemiology (K.C.P., B.R.) and Environmental Health (J.M.B., B.R.), Fielding School of Public Health, and Department of Neurology (J.M.B., B.R.), Geffen School of Medicine, University of California at Los Angeles; and Université Paris-Saclay (A.E.), Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.
Marie-Anne LoriotFrom the Department of Health Care Management (P.-C.L.), College of Health Technology, National Taipei University of Nursing and Health Sciences, Taiwan; Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (I.A.), INSERM, UVSQ, Institut Pasteur, Université Paris-Saclay, Villejuif; Assistance-Publique-Hôpitaux de Paris (M.-A.L.), Hôpital Européen Georges Pompidou, Biochimie, Pharmacogénétique et Oncologie Moléculaire; INSERM UMR-S 1147 (C.M.), CRB EPIGENETEC, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Departments of Epidemiology (K.C.P., B.R.) and Environmental Health (J.M.B., B.R.), Fielding School of Public Health, and Department of Neurology (J.M.B., B.R.), Geffen School of Medicine, University of California at Los Angeles; and Université Paris-Saclay (A.E.), Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.
Claire MulotFrom the Department of Health Care Management (P.-C.L.), College of Health Technology, National Taipei University of Nursing and Health Sciences, Taiwan; Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (I.A.), INSERM, UVSQ, Institut Pasteur, Université Paris-Saclay, Villejuif; Assistance-Publique-Hôpitaux de Paris (M.-A.L.), Hôpital Européen Georges Pompidou, Biochimie, Pharmacogénétique et Oncologie Moléculaire; INSERM UMR-S 1147 (C.M.), CRB EPIGENETEC, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Departments of Epidemiology (K.C.P., B.R.) and Environmental Health (J.M.B., B.R.), Fielding School of Public Health, and Department of Neurology (J.M.B., B.R.), Geffen School of Medicine, University of California at Los Angeles; and Université Paris-Saclay (A.E.), Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.
Kimberly C PaulFrom the Department of Health Care Management (P.-C.L.), College of Health Technology, National Taipei University of Nursing and Health Sciences, Taiwan; Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (I.A.), INSERM, UVSQ, Institut Pasteur, Université Paris-Saclay, Villejuif; Assistance-Publique-Hôpitaux de Paris (M.-A.L.), Hôpital Européen Georges Pompidou, Biochimie, Pharmacogénétique et Oncologie Moléculaire; INSERM UMR-S 1147 (C.M.), CRB EPIGENETEC, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Departments of Epidemiology (K.C.P., B.R.) and Environmental Health (J.M.B., B.R.), Fielding School of Public Health, and Department of Neurology (J.M.B., B.R.), Geffen School of Medicine, University of California at Los Angeles; and Université Paris-Saclay (A.E.), Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.
Jeff M BronsteinFrom the Department of Health Care Management (P.-C.L.), College of Health Technology, National Taipei University of Nursing and Health Sciences, Taiwan; Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (I.A.), INSERM, UVSQ, Institut Pasteur, Université Paris-Saclay, Villejuif; Assistance-Publique-Hôpitaux de Paris (M.-A.L.), Hôpital Européen Georges Pompidou, Biochimie, Pharmacogénétique et Oncologie Moléculaire; INSERM UMR-S 1147 (C.M.), CRB EPIGENETEC, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Departments of Epidemiology (K.C.P., B.R.) and Environmental Health (J.M.B., B.R.), Fielding School of Public Health, and Department of Neurology (J.M.B., B.R.), Geffen School of Medicine, University of California at Los Angeles; and Université Paris-Saclay (A.E.), Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.
Beate RitzFrom the Department of Health Care Management (P.-C.L.), College of Health Technology, National Taipei University of Nursing and Health Sciences, Taiwan; Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (I.A.), INSERM, UVSQ, Institut Pasteur, Université Paris-Saclay, Villejuif; Assistance-Publique-Hôpitaux de Paris (M.-A.L.), Hôpital Européen Georges Pompidou, Biochimie, Pharmacogénétique et Oncologie Moléculaire; INSERM UMR-S 1147 (C.M.), CRB EPIGENETEC, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Departments of Epidemiology (K.C.P., B.R.) and Environmental Health (J.M.B., B.R.), Fielding School of Public Health, and Department of Neurology (J.M.B., B.R.), Geffen School of Medicine, University of California at Los Angeles; and Université Paris-Saclay (A.E.), Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.
Alexis ElbazFrom the Department of Health Care Management (P.-C.L.), College of Health Technology, National Taipei University of Nursing and Health Sciences, Taiwan; Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (I.A.), INSERM, UVSQ, Institut Pasteur, Université Paris-Saclay, Villejuif; Assistance-Publique-Hôpitaux de Paris (M.-A.L.), Hôpital Européen Georges Pompidou, Biochimie, Pharmacogénétique et Oncologie Moléculaire; INSERM UMR-S 1147 (C.M.), CRB EPIGENETEC, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Departments of Epidemiology (K.C.P., B.R.) and Environmental Health (J.M.B., B.R.), Fielding School of Public Health, and Department of Neurology (J.M.B., B.R.), Geffen School of Medicine, University of California at Los Angeles; and Université Paris-Saclay (A.E.), Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France. alexis.elbaz@inserm.fr.
University of California, Los Angeles · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate whether cigarette smoking interacts with genes involved in individual susceptibility to xenobiotics for the risk of Parkinson disease (PD).
methodsTwo French population-based case-control studies (513 patients, 1,147 controls) were included as a discovery sample to examine gene-smoking interactions based on 3,179 single nucleotide polymorphisms (SNPs) in 289 genes involved in individual susceptibility to xenobiotics. SNP-by-cigarette smoking interactions were tested in the discovery sample through an empirical Bayes (EB) approach. Nine SNPs were selected for replication in a population-based case-control study from California (410 patients, 845 controls) with standard logistic regression and the EB approach. For SNPs that replicated, we performed pooled analyses including the discovery and replication datasets and computed pooled odds ratios and confidence intervals (CIs) using random-effects meta-analysis.
resultsNine SNPs interacted with smoking in the discovery dataset and were selected for replication. Interactions of smoking with rs4240705 in the
conclusionsWe identified and replicated suggestive gene-by-smoking interactions in PD. The inverse association of smoking with PD was less pronounced in carriers of minor alleles of both
Indexed as
Polymorphism, Single NucleotideAdultAgedAged, 80 and overBayes TheoremCase-Control StudiesFemaleGene-Environment InteractionGenetic Association StudiesGenetic Predisposition to DiseaseHeterozygoteHumansMaleMiddle AgedParkinson DiseaseRetinoid X Receptor alphaRetinoid X Receptor alphaRXRA protein, humanSLC17A6 protein, humanVesicular Glutamate Transport Protein 2
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.