ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2018
The surprising subtleties of changing fear memory: a challenge for translational science.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 78 citations in OpenAlex.
- Attenuating trauma- and cocaine-related intrusions by blocking memory reconsolidation with minocycline: protocol for a transdiagnostic randomized controlled trial.European journal of psychotraumatology · 2026Trial
- Re-encountering the phobic cue within days after a reconsolidation intervention is crucial to observe a lasting fear reduction in spider phobia.Molecular psychiatry · 2025Trial
- Re-encountering the phobic cue within days after a reconsolidation intervention is crucial to observe a lasting fear reduction in spider phobia.Molecular psychiatry · 2025Trial
- Psychophysiological Outcome Responses in Human Pavlovian Fear Conditioning: A Prediction Error Analysis.Psychophysiology · 2026Article
- A mechanistic trial of the neurobiology of extinction learning and intraparietal sulcus stimulation: Protocol.Contemporary clinical trials communications · 2026Article
- An EEG Dataset of Exploring Navigation in Virtual Reality.Scientific data · 2025Article
- Targeted memory reactivation during sleep improves emotional memory modulation following imagery rescripting.Translational psychiatry · 2024Article
- Article
- Survival Bias, Non-Lineal Behavioral and Cortico-Limbic Neuropathological Signatures in 3xTg-AD Mice for Alzheimer's Disease from Premorbid to Advanced Stages and Compared to Normal Aging.International journal of molecular sciences · 2023Article
- Injury, illness, and emotion: A review of the motivational continuum from trauma through recovery from an ecological perspective.Brain, behavior, & immunity - health · 2023Review
- A brief treatment for veterans with PTSD: an open-label case-series study.Frontiers in psychiatry · 2023Article
- Reactivating hippocampal-mediated memories during reconsolidation to disrupt fear.Nature communications · 2022Article
- Belief traps: Tackling the inertia of harmful beliefs.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Contextual memory reactivation modulates CaScientific reports · 2022Article
- Over the Edge: Extending the duration of a reconsolidation intervention for spider fear.Translational psychiatry · 2022Article
- Improvement of episodic memory retention by a memory reactivation intervention across the lifespan: from younger adults to amnesic patients.Translational psychiatry · 2022Article
- Continuous theta-burst stimulation over the right dorsolateral prefrontal cortex disrupts fear memory reconsolidation in humans.iScience · 2022Article
- Perioperative Propranolol Against Dental Anxiety: A Randomized Controlled Trial.Frontiers in psychiatry · 2022Article
- Apparent reconsolidation interference without generalized amnesia.Progress in neuro-psychopharmacology & biological psychiatry · 2021Article
- Preventing Post Traumatic Stress Disorder in the general population induced by trauma during the COVID pandemic: A simple brief intervention based on cognitive science that could be delivered digitally.European journal of trauma & dissociation = Revue europeenne du trauma et de la dissociation · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current pharmacological and psychological treatments for disorders of emotional memory only dampen the affective response while leaving the original fear memory intact. Under adverse circumstances, these original memories regain prominence, causing relapses in many patients. The (re)discovery in neuroscience that after reactivation consolidated fear memories may return to a transient labile state, requiring a process of restabilization in order to persist, offers a window of opportunity for modifying fear memories with amnestic agents. This process, known as memory reconsolidation, opens avenues for developing a revolutionary treatment for emotional memory disorders. The reconsolidation intervention challenges the dominant pharmacological and psychological models of treatment: it is only effective when the amnestic drug is given in conjunction with memory reactivation during a specific time window, and a modification of cognitive processes is a boundary condition for changing fear. Notwithstanding the dramatic effects of targeting memory reconsolidation in the laboratory (i.e. proof of principle), the greatest hurdle to overcome is that the success of the manipulation depends on subtle differences in the reactivation procedure. These experimental parameters cannot be easily controlled in clinical practice. In harnessing the clinical potential of memory reconsolidation, a heuristic for
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.