Evidence map›Paper›PMID 29352027›Full record

ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2018

The thalamus in drug addiction: from rodents to humans.

Anna S Huang, Jameson A Mitchell, Suzanne N Haber, Nelly Alia-Klein, Rita Z Goldstein

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 6 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 6 syntheses or guidelines pooled it, 123 citations in OpenAlex.

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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Anna S HuangDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jameson A MitchellSchool of General Studies, Columbia University, New York, NY, USA.
Suzanne N HaberDepartment of Pharmacology and Physiology, School of Medicine, University of Rochester, Rochester, NY, USA.
Nelly Alia-KleinDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Rita Z GoldsteinDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA rita.goldstein@mssm.edu.ORCID 0000-0002-1127-028X
Icahn School of Medicine at Mount Sinai · USColumbia University · USUniversity of Rochester · US

Funding

Using event-related potentials to longitudinally track cue-induced craving incubation in cocaine addicted individualsR01DA041528 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GOLDSTEIN, RITA Z · 2016 to 2020
$3.3M
Neurocircuitry of impaired insight in addiction: relevance to aberrant self-related processingR21DA040046 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MOELLER, SCOTT J · 2015 to 2016
$459k
NIDA NIH HHS R01 DA041528NIDA NIH HHS R21 DA040046
6 · The paper itself

Abstract

Impairments in response inhibition and salience attribution (iRISA) have been proposed to underlie the clinical symptoms of drug addiction as mediated by cortico-striatal-thalamo-cortical networks. The bulk of evidence supporting the iRISA model comes from neuroimaging research that has focused on cortical and striatal influences with less emphasis on the role of the thalamus. Here, we highlight the importance of the thalamus in drug addiction, focusing on animal literature findings on thalamic nuclei in the context of drug-seeking, structural and functional changes of the thalamus as measured by imaging studies in human drug addiction, particularly during drug cue and non-drug reward processing, and response inhibition tasks. Findings from the animal literature suggest that the paraventricular nucleus of the thalamus, the lateral habenula and the mediodorsal nucleus may be involved in the reinstatement, extinction and expression of drug-seeking behaviours. In support of the iRISA model, the human addiction imaging literature demonstrates enhanced thalamus activation when reacting to drug cues and reduced thalamus activation during response inhibition. This pattern of response was further associated with the severity of, and relapse in, drug addiction. Future animal studies could widen their field of focus by investigating the specific role(s) of different thalamic nuclei in different phases of the addiction cycle. Similarly, future human imaging studies should aim to specifically delineate the structure and function of different thalamic nuclei, for example, through the application of advanced imaging protocols at higher magnetic fields (7 Tesla).This article is part of a discussion meeting issue 'Of mice and mental health: facilitating dialogue between basic and clinical neuroscientists'.

Indexed as

AnimalsDrug-Seeking BehaviorHumansRodentiaSubstance-Related DisordersThalamuscue reactivitydrug self-administrationfunctional MRIresponse inhibitionsubstance use disordersthalamus

Identifiers

PMID29352027
PMCPMC5790826
OpenAlexW2785762584

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.