ArticleGenes & development2017
Opposing roles of TGFβ and BMP signaling in prostate cancer development.
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Article in Genes & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
–field-weighted citation impact
What it found
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- A Comprehensive Review Exploring the Role of Bone Morphogenetic Proteins [BMP]: Biological Mechanisms.Current issues in molecular biology · 2025Review
- BMP signaling in cancer stemness and differentiation.Cell regeneration (London, England) · 2023Review
- Potential of bone morphogenetic protein-7 in treatment of lupus nephritis: addressing the hurdles to implementation.Inflammopharmacology · 2023Review
- Intra-epithelial non-canonical Activin A signaling safeguards prostate progenitor quiescence.EMBO reports · 2022Article
- Sec62 promotes gastric cancer metastasis through mediating UPR-induced autophagy activation.Cellular and molecular life sciences : CMLS · 2022Article
- SMAD4 Feedback Activates the Canonical TGF-β Family Signaling Pathways.International journal of molecular sciences · 2021Article
- Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α-AKT-mTOR pathway in esophageal squamous cell carcinoma.Cell & bioscience · 2021Article
- Imbalance of TGF-β1/BMP-7 pathways induced by M2-polarized macrophages promotes hepatocellular carcinoma aggressiveness.Molecular therapy : the journal of the American Society of Gene Therapy · 2021Article
- Aspirin overcomes cisplatin resistance in lung cancer by inhibiting cancer cell stemness.Thoracic cancer · 2020Article
- Regulation of stem/progenitor cell maintenance by BMP5 in prostate homeostasis and cancer initiation.eLife · 2020Article
- Prostate cancer research: The next generation; report from the 2019 Coffey-Holden Prostate Cancer Academy Meeting.The Prostate · 2020Review
- Intra-arterial injection to create bone metastasis of prostate cancer in mice.American journal of clinical and experimental urology · 2020Article
- Identification of genes in hepatocellular carcinoma induced by non-alcoholic fatty liver disease.Cancer biomarkers : section A of Disease markers · 2020Article
- Phospholipase C (PLC)ε Promotes Androgen Receptor Antagonist Resistance via the Bone Morphogenetic Protein (BMP)-6/SMAD Axis in a Castration-Resistant Prostate Cancer Cell Line.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Relationship between ETS Transcription Factor ETV1 and TGF-β-regulated SMAD Proteins in Prostate Cancer.Scientific reports · 2019Article
- TRIM47 is up-regulated in colorectal cancer, promoting ubiquitination and degradation of SMAD4.Journal of experimental & clinical cancer research : CR · 2019Article
- Opposing roles and potential antagonistic mechanism between TGF-β and BMP pathways: Implications for cancer progression.EBioMedicine · 2019Review
- Genetics and biology of prostate cancer.Genes & development · 2018Review
- GDF11 restrains tumor growth by promoting apoptosis in pancreatic cancer.OncoTargets and therapy · 2018Article
- Pan-cancer multi-omics analysis to identify the potential pro-oncogenic properties of GREM1 as a promising targets for cancer prognosis and therapeutics.International journal of immunopathology and pharmacologyArticle
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 3 countries.
Xin LuDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Eun-Jung JinDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Xi ChengDepartment of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana 46556, USA.
Shan FengDepartment of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana 46556, USA.
Xiaoying ShangDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Pingna DengDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Shan JiangInstitute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Qing ChangInstitute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Sharif RahmyDepartment of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana 46556, USA.
Seema ChaudharyDepartment of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana 46556, USA.
Xuemin LuDepartment of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana 46556, USA.
Ren ZhaoDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Y Alan WangDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Ronald A DePinhoDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
The University of Texas MD Anderson Cancer Center · USUniversity of Notre Dame · USIndiana University Health · USRuijin Hospital · CNShanghai Jiao Tong University · CNTsinghua University · CNWonkwang University · KR
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8MThe RAS and P13K Pathways in Pancreatic AdenocarcinomaP01CA117969 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DEPINHO, RONALD ANTHONY · 2006 to 2025
$41.7MIndiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3MTELOMERASE IN DEVELOPMENT, SENESCENCE AND NEOPLASIAR01CA084628 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DEPINHO, RONALD ANTHONY · 2000 to 2019
$10.5MIndiana Clinical and Translational Sciences InstituteKL2TR001106 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$3.2MNCATS NIH HHS KL2 TR001106NCATS NIH HHS UL1 TR001108NCI NIH HHS P01 CA117969NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA084628
Abstract
SMAD4 constrains progression of
Indexed as
Signal TransductionAnimalsBone Morphogenetic Protein Receptors, Type IIBone NeoplasmsDisease Models, AnimalGene DeletionGene Expression ProfilingGene Expression Regulation, NeoplasticGenotypeKaplan-Meier EstimateMaleMiceMice, Inbred C57BLProstatic NeoplasmsProtein Serine-Threonine KinasesPTEN PhosphohydrolaseBone Morphogenetic Protein Receptors, Type IIProtein Serine-Threonine KinasesPTEN PhosphohydrolaseReceptors, Transforming Growth Factor betaReceptor, Transforming Growth Factor-beta Type IISmad4 ProteinBMPR2bone metastasisprostate cancerPTENSMAD4TGFBR2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.