Evidence map›Paper›PMID 29352017›Full record

ArticleGenes & development2017

Keeping it real: MRX-Sae2 clipping of natural substrates.

Robert Gnügge, Lorraine S Symington

Open access · diamondAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Mechanism and Control of Meiotic DNA Double-Strand Break Formation inFrontiers in cell and developmental biology · 2021
    Review
  5. Review
  6. CtIP is essential for telomere replication.Nucleic acids research · 2019
    Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Robert GnüggeDepartment of Microbiology and Immunology, Columbia University Medical Center, New York, New York 10032, USA.
Lorraine S SymingtonDepartment of Microbiology and Immunology, Columbia University Medical Center, New York, New York 10032, USA.
Columbia University Irving Medical Center · US

Funding

The Role of CTIP in Lymphocyte Development and LymphomagenesisP01CA174653 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RABADAN, RAUL · 2014 to 2024
$17.6M
Mechanisms of Homologous Recombination in YeastR01GM041784 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SYMINGTON, LORRAINE S · 1989 to 2017
$7.8M
NCI NIH HHS P01 CA174653NIGMS NIH HHS R01 GM041784
6 · The paper itself

Abstract

The yeast Mre11-Rad50-Xrs2 (MRX) complex and Sae2 function together to initiate DNA end resection, an essential early step in homology-dependent repair of DNA double-strand breaks (DSBs). In this issue of

Indexed as

DNA-Binding ProteinsDNA Breaks, Double-StrandedDNA RepairEndodeoxyribonucleasesExodeoxyribonucleasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsDNA-Binding ProteinsEndodeoxyribonucleasesExodeoxyribonucleasesSaccharomyces cerevisiae ProteinsDNA end resectionhomologous recombinationKu70–Ku80MRX–Sae2nucleasenucleosomeRPA

Identifiers

PMID29352017
PMCPMC5795777
OpenAlexW2790380457

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.