Evidence map›Paper›PMID 29352002›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

Intestinal Epithelial Cell-Derived LKB1 Suppresses Colitogenic Microbiota.

Xia'nan Liu, Jinfeng Lu, Zhenshan Liu, Junjie Zhao, Hongxiang Sun, Ningbo Wu, Hongzhi Liu, Weiwei Liu, Zhuqin Hu, Guangxun Meng and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Editorial: The mucosal barrier to infection.Frontiers in cellular and infection microbiology · 2023
    Article
  4. Frontiers in microbiology · 2023
    Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Xia'nan LiuShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Jinfeng LuShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Zhenshan LiuShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Junjie ZhaoDepartment of Immunology, Cleveland Clinic, Cleveland, OH 44195.
Hongxiang SunShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Ningbo WuShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID 0000-0002-9900-4401
Hongzhi LiuShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Weiwei LiuShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Zhuqin HuShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Guangxun MengKey Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0003-4634-4661
Lei ShenShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Aaron W MillerDepartment of Immunology, Cleveland Clinic, Cleveland, OH 44195.
Bing SuShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID 0000-0003-0871-7666
Xiaoxia LiDepartment of Immunology, Cleveland Clinic, Cleveland, OH 44195.
Zizhen KangShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; kangz@ccf.org.ORCID 0000-0001-5621-8912
Shanghai Jiao Tong University · CNCleveland Clinic · USChinese Academy of Sciences · CN

Funding

THE INTEGRATION OF IL-17 AND NOTCH SIGNALING IN THE PATHOGENESIS OF CNS INFLAMMATIONR01NS104164 · NINDS · UNIVERSITY OF IOWA · PI KANG, ZIZHEN · 2018 to 2022
$1.7M
NINDS NIH HHS R01 NS104164
6 · The paper itself

Abstract

Dysregulation of the immune barrier function of the intestinal epithelium can often result in dysbiosis. In this study we report a novel role of intestinal epithelial cell (IEC)-derived liver kinase B1 (LKB1) in suppressing colitogenic microbiota. IEC-specific deletion of LKB1 (LKB1

Indexed as

AMP-Activated Protein KinasesAnimalsColitisColonDextran SulfateDysbiosisEpithelial CellsInterleukin-18Intestinal MucosaIntestinesMiceMice, Inbred C57BLMicrobiotaProtein Serine-Threonine KinasesAMP-Activated Protein KinasesDextran SulfateInterleukin-18Protein Serine-Threonine KinasesStk11 protein, mouse

Identifiers

PMID29352002
PMCPMC6814173
OpenAlexW2782663760

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.