Evidence map›Paper›PMID 29351999›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

MLL1 Promotes IL-7 Responsiveness and Survival during B Cell Differentiation.

Tao Gan, Bin E Li, Bibhu P Mishra, Kenneth L Jones, Patricia Ernst

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. B Cells and Microbiota in Autoimmunity.International journal of molecular sciences · 2021
    Review
  3. The MLL/SET family and haematopoiesis.Biochimica et biophysica acta. Gene regulatory mechanisms · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Tao GanDepartment of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.
Bin E LiDepartment of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.
Bibhu P MishraDepartment of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.
Kenneth L JonesHematology/Oncology/Bone Marrow Transplant Section, Department of Pediatrics, University of Colorado, Denver/Anschutz Medical Campus, Aurora, CO 80045; and.
Patricia ErnstHematology/Oncology/Bone Marrow Transplant Section, Department of Pediatrics, University of Colorado, Denver/Anschutz Medical Campus, Aurora, CO 80045; and patricia.ernst@ucdenver.edu.ORCID 0000-0001-7638-2939
Dartmouth College · USUniversity of Colorado Anschutz Medical Campus · US

Funding

MLL Function in the Maintenance of the Blood Forming SystemR01HL090036 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ERNST, PATRICIA · 2007 to 2015
$3.8M
Connecting Epigenetic Regulator MLL1 to ERK and Survival Signaling in B cellsR21AI129426 · NIAID · UNIVERSITY OF COLORADO DENVER · PI ERNST, PATRICIA · 2017 to 2018
$418k
NHLBI NIH HHS R01 HL090036NIAID NIH HHS R21 AI129426
6 · The paper itself

Abstract

B lymphocyte differentiation is an exquisitely regulated homeostatic process resulting in continuous production of appropriately selected B cells. Relatively small changes in gene expression can result in deregulation of this process, leading to acute lymphocytic leukemia (ALL), immune deficiency, or autoimmunity. Translocation of

Indexed as

AnimalsB-LymphocytesCell DifferentiationCells, CulturedFemaleHistone-Lysine N-MethyltransferaseHomeostasisInterleukin-7Lymphocyte ActivationMiceMice, Inbred C57BLMyeloid-Lymphoid Leukemia ProteinPrecursor Cells, B-LymphoidSignal TransductionHistone-Lysine N-MethyltransferaseInterleukin-7Kmt2a protein, mouseMyeloid-Lymphoid Leukemia Protein

Identifiers

PMID29351999
PMCPMC5909838
OpenAlexW2783083276

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.