Evidence map›Paper›PMID 29351996›Full record

ArticleThe Journal of cell biology2018

Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7.

Yang Yue, T Lynne Blasius, Stephanie Zhang, Shashank Jariwala, Benjamin Walker, Barry J Grant, Jared C Cochran, Kristen J Verhey

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in The Journal of cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 39 citations in OpenAlex.

  1. Microtubule Engagement by the WD40-Containing Tail of Kinesin-4 KIF21B.bioRxiv : the preprint server for biology · 2026
    Article
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  3. CLASP2 promotes repair of kinesin-1 damage to the microtubule lattice.bioRxiv : the preprint server for biology · 2026
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  7. The kinesin-4 protein KIF27 forms a cytoskeletal scaffold at the transition zone to promote motile cilia structural integrity.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yang YueDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI.ORCID 0000-0002-8302-9778
T Lynne BlasiusDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI.ORCID 0000-0003-3190-4304
Stephanie ZhangDepartment of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN.ORCID 0000-0001-7750-5371
Shashank JariwalaDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI.
Benjamin WalkerDepartment of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN.ORCID 0000-0002-2074-2314
Barry J GrantDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI.ORCID 0000-0002-2215-4196
Jared C CochranDepartment of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN.
Kristen J VerheyDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI kjverhey@umich.edu.ORCID 0000-0001-9329-4981
University of Michigan · USIndiana University Bloomington · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
DROSOPHILA GENOMICS RESOURCE CENTERP40OD010949 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Andrew Zelhof · 2012 to 2026
$9.4M
Regulation of the molecular motor kinesin-IR01GM070862 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VERHEY, KRISTEN J. · 2005 to 2018
$4.2M
NIDDK NIH HHS P30 DK020572NIGMS NIH HHS R01 GM070862NIH HHS P40 OD010949
6 · The paper itself

Abstract

Kinesin-4 motors play important roles in cell division, microtubule organization, and signaling. Understanding how motors perform their functions requires an understanding of their mechanochemical and motility properties. We demonstrate that KIF27 can influence microtubule dynamics, suggesting a conserved function in microtubule organization across the kinesin-4 family. However, kinesin-4 motors display dramatically different motility characteristics: KIF4 and KIF21 motors are fast and processive, KIF7 and its

Indexed as

Adenosine TriphosphateAnimalsCatalysisChlorocebus aethiopsCOS CellsDrosophila melanogasterDrosophila ProteinsEvolution, MolecularHydrolysisKinesinsKineticsMicroscopy, FluorescenceMicrotubulesPhylogenyProtein TransportSignal TransductionAdenosine Triphosphatecos protein, DrosophilaDrosophila ProteinsKif7 protein, mouseKinesins

Identifiers

PMID29351996
PMCPMC5881503
OpenAlexW2784751262

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.