Evidence map›Paper›PMID 29351992›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Involvement of Aryl hydrocarbon receptor in myelination and in human nerve sheath tumorigenesis.

Ghjuvan'Ghjacumu Shackleford, Nirmal Kumar Sampathkumar, Mehdi Hichor, Laure Weill, Delphine Meffre, Ludmila Juricek, Ingrid Laurendeau, Aline Chevallier, Nicolas Ortonne, Frédérique Larousserie and 8 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 39 citations in OpenAlex.

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  14. AhR and Wnt/β-Catenin Signaling Pathways and Their Interplay.Current issues in molecular biology · 2023
    Review
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  16. Identification of Modulators of theAntioxidants (Basel, Switzerland) · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 1 country.

Ghjuvan'Ghjacumu ShacklefordUniversity Paris Descartes, INSERM UMR 1124, Faculty of Basic and Biomedical Sciences, 75270 Paris Cedex 6, France.
Nirmal Kumar SampathkumarUniversity Paris Descartes, INSERM UMR 1124, Faculty of Basic and Biomedical Sciences, 75270 Paris Cedex 6, France.
Mehdi HichorUniversity Paris Descartes, INSERM UMR 1124, Faculty of Basic and Biomedical Sciences, 75270 Paris Cedex 6, France.
Laure WeillUniversity Paris Descartes, INSERM UMR 1124, Faculty of Basic and Biomedical Sciences, 75270 Paris Cedex 6, France.
Delphine MeffreUniversity Paris Descartes, INSERM UMR 1124, Faculty of Basic and Biomedical Sciences, 75270 Paris Cedex 6, France.
Ludmila JuricekUniversity Paris Descartes, INSERM UMR 1124, Faculty of Basic and Biomedical Sciences, 75270 Paris Cedex 6, France.
Ingrid LaurendeauEA7331, Université Paris Descartes, Faculté de Pharmacie de Paris, 75270 Paris Cedex 6, France.
Aline ChevallierUniversity Paris Descartes, INSERM UMR 1124, Faculty of Basic and Biomedical Sciences, 75270 Paris Cedex 6, France.
Nicolas OrtonneDepartment of Pathology, Henri Mondor Hospital, 94010 Créteil, France.
Frédérique LarousserieDepartment of Pathology, Cochin Hospital, 75014 Paris, France.
Marc HerbinCNRS UMR 7179, Département Ecologie et Gestion de la Biodiversité, Muséum National d'Histoire Naturelle, 75231 Paris Cedex 5, France.
Ivan BiècheEA7331, Université Paris Descartes, Faculté de Pharmacie de Paris, 75270 Paris Cedex 6, France.
Xavier CoumoulUniversity Paris Descartes, INSERM UMR 1124, Faculty of Basic and Biomedical Sciences, 75270 Paris Cedex 6, France.
Mathieu BeraneckUniversity Paris Descartes, CNRS UMR 8119, Faculty of Basic and Biomedical Sciences, 75270 Paris Cedex 6, France.
Etienne-Emile BaulieuParis-Saclay University, INSERM UMR-1195, 94276 Le Kremlin-Bicêtre Cedex, France etienne.baulieu@inserm.fr Charbel.massaad@parisdescartes.fr.
Frédéric CharbonnierUniversity Paris Descartes, INSERM UMR 1124, Faculty of Basic and Biomedical Sciences, 75270 Paris Cedex 6, France.
Eric PasmantEA7331, Université Paris Descartes, Faculté de Pharmacie de Paris, 75270 Paris Cedex 6, France.
Charbel MassaadUniversity Paris Descartes, INSERM UMR 1124, Faculty of Basic and Biomedical Sciences, 75270 Paris Cedex 6, France; etienne.baulieu@inserm.fr Charbel.massaad@parisdescartes.fr.
Inserm · FRUniversité Paris Cité · FRCentre National de la Recherche Scientifique · FRDélégation Paris 5 · FRHôpital Cochin · FRHôpitaux Universitaires Henri-Mondor · FRUniversité Paris-Saclay · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor involved in xenobiotic metabolism. Plexiform neurofibromas (PNFs) can transform into malignant peripheral nerve sheath tumors (MPNSTs) that are resistant to existing therapies. These tumors are primarily composed of Schwann cells. In addition to neurofibromatosis type 1 (

Indexed as

Gene Expression Regulation, NeoplasticAnimalsApoptosisBasic Helix-Loop-Helix ProteinsCells, CulturedCell Transformation, NeoplasticHumansMaleMiceMice, Inbred C57BLMyelin SheathNerve Sheath NeoplasmsReceptors, Aryl HydrocarbonSignal TransductionAHR protein, humanAhr protein, mouseBasic Helix-Loop-Helix ProteinsReceptors, Aryl HydrocarbonAHRMPNSTmyelinnerveneurofibroma

Identifiers

PMID29351992
PMCPMC5819423
OpenAlexW2783130112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.