Evidence map›Paper›PMID 29351920›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Exceptional Response to Pembrolizumab in a Metastatic, Chemotherapy/Radiation-Resistant Ovarian Cancer Patient Harboring a PD-L1-Genetic Rearrangement.

Stefania Bellone, Natalia Buza, Jungmin Choi, Luca Zammataro, Laurie Gay, Julia Elvin, David L Rimm, Yuting Liu, Elena S Ratner, Peter E Schwartz and 1 more

Abstract readCase Reports
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 48 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Review
  5. Personalized Versus Precision Nanomedicine for Treatment of Ovarian Cancer.Small (Weinheim an der Bergstrasse, Germany) · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Development of an immunohistochemical assay for Siglec-15.Laboratory investigation; a journal of technical methods and pathology · 2022
    Article
  14. Targeting immune checkpoints in gynecologic cancer: updates & perspectives for pathologists.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022
    Review
  15. Article
  16. Pan-cancer landscape ofJournal for immunotherapy of cancer · 2021
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Stefania BelloneDepartment of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut.
Natalia BuzaDepartment of Pathology, Yale University School of Medicine, New Haven, Connecticut.
Jungmin ChoiDepartment of Genetics, Yale University School of Medicine, New Haven, Connecticut.
Luca ZammataroDepartment of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut.
Laurie GayFoundation Medicine, Cambridge, Massachusetts.
Julia ElvinFoundation Medicine, Cambridge, Massachusetts.
David L RimmDepartment of Pathology, Yale University School of Medicine, New Haven, Connecticut.
Yuting LiuDepartment of Pathology, Yale University School of Medicine, New Haven, Connecticut.
Elena S RatnerDepartment of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut.
Peter E SchwartzDepartment of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut.
Alessandro D SantinDepartment of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut. alessandro.santin@yale.edu.
Yale University · US

Funding

Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI DAVID L RIMM · 1985 to 2026
$85.0M
Integrated genomic analysis of racial disparities in endometrial cancerU01CA176067 · NCI · YALE UNIVERSITY · PI SANTIN, ALESSANDRO D · 2014 to 2018
$1.7M
NCI NIH HHS P30 CA016359NCI NIH HHS U01 CA176067
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene RearrangementAged, 80 and overAntibodies, Monoclonal, HumanizedAntineoplastic Agents, ImmunologicalB7-H1 AntigenBiomarkers, TumorBiopsyComputational BiologyDrug Resistance, NeoplasmExome SequencingFemaleHLA AntigensHumansMolecular Targeted TherapyMutationOvarian NeoplasmsAntibodies, Monoclonal, HumanizedAntineoplastic Agents, ImmunologicalB7-H1 AntigenBiomarkers, TumorCD274 protein, humanHLA AntigenspembrolizumabPLGRKT protein, humanProgrammed Cell Death 1 ReceptorReceptors, Cell Surface

Identifiers

PMID29351920
PMCPMC6050068
OpenAlexW2790823295

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.