ArticleNeurobiology of aging2018
Low cortical iron and high entorhinal cortex volume promote cognitive functioning in the oldest-old.
Article in Neurobiology of aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
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- Could Blood Transfusion Increase the Risk of Alzheimer's Disease? A Narrative Review.Healthcare (Basel, Switzerland) · 2025Review
- The characteristic patterns of individual brain susceptibility networks underlie Alzheimer's disease and white matter hyperintensity-related cognitive impairment.Translational psychiatry · 2024Article
- Review
- Cognition and brain iron deposition in whole grey matter regions and hippocampal subfields.The European journal of neuroscience · 2022Article
- Bridging patterns of neurocognitive aging across the older adult lifespan.Neuroscience and biobehavioral reviews · 2022Review
- Low Subicular Volume as an Indicator of Dementia-Risk Susceptibility in Old Age.Frontiers in aging neuroscience · 2022Article
- Amyloid-β, cortical thickness, and subsequent cognitive decline in cognitively normal oldest-old.Annals of clinical and translational neurology · 2021Article
- Neuroimaging in the Oldest-Old: A Review of the Literature.Journal of Alzheimer's disease : JAD · 2021Review
- Article
- APOE4 moderates effects of cortical iron on synchronized default mode network activity in cognitively healthy old-aged adults.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Functional Brain Network Connectivity Patterns Associated With Normal Cognition at Old-Age, Local β-amyloid, Tau, and APOE4.Frontiers in aging neuroscience · 2020Article
- Effect of Off-Target Binding onJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019Article
- Increased cerebral blood volume in small arterial vessels is a correlate of amyloid-β-related cognitive decline.Neurobiology of aging · 2019Article
- Background field removal for susceptibility mapping of human brain with large susceptibility variations.Magnetic resonance in medicine · 2019Article
- Article
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Authors and funding
13 authors at 5 institutions in 2 countries.
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Abstract
The aging brain is characterized by an increased presence of neurodegenerative and vascular pathologies. However, there is substantial variation regarding the relationship between an individual's pathological burden and resulting cognitive impairment. To identify correlates of preserved cognitive functioning at highest age, the relationship between β-amyloid plaque load, presence of small vessel cerebrovascular disease (SVCD), iron-burden, and brain atrophy was investigated. Eighty cognitively unimpaired participants (44 oldest-old, aged 85-96 years; 36 younger-old, aged 55-80 years) were scanned by integrated positron emission tomography-magnetic resonance imaging for assessing beta regional amyloid plaque load (18F-flutemetamol), white matter hyperintensities as an indicator of SVCD (fluid-attenuated inversion recovery-magnetic resonance imaging), and iron load (quantitative susceptibility mapping). For the oldest-old group, lower cortical volume, increased β-amyloid plaque load, prevalence of SVCD, and lower cognitive performance in the normal range were found. However, compared to normal-old, cortical iron burden was lower in the oldest-old. Moreover, only in the oldest-old, entorhinal cortex volume positively correlated with β-amyloid plaque load. Our data thus indicate that the co-occurrence of aging-associated neuropathologies with reduced quantitative susceptibility mapping measures of cortical iron load constitutes a lower vulnerability to cognitive loss.
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