SynthesisCritical care (London, England)2018
Tracheal intubation in critically ill patients: a comprehensive systematic review of randomized trials.
Synthesis in Critical care (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Association of Checklist Use in Endotracheal Intubation With Clinically Important Outcomes: A Systematic Review and Meta-analysis.JAMA network open · 2020Pooled it
- Video laryngoscopy as a teaching tool in direct intubation in undergraduate medical education - a randomized controlled trial.BMC medical education · 2026Trial
- Utilization of intubation kits and checklist to improve first-pass success and reduce complications associated with endotracheal intubation in Rwanda.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2026Article
- Unprepared airway: an ABCDE preparation framework for emergency intubation.World journal of emergency medicine · 2026Article
- Observational
- Measures to prevent acute airway obstruction after anterior cervical spine surgery: a retrospective cohort study from Japan and a review of the literature.Asian spine journal · 2025Article
- Impact of Checklist Implementation on Endotracheal Intubation-Related Complications in Critically Ill Adults-A Retrospective Before and After Study.Acta anaesthesiologica Scandinavica · 2025Observational
- High-flow nasal cannula oxygen therapy: physiological basis and clinical applications in anesthesia.Frontiers in medicine · 2025Review
- Impact of Operating Table Height on the Difficulty of Mask Ventilation and Laryngoscopic View.Journal of clinical medicine · 2024Article
- Tracheal intubation in critically ill adults with a physiologically difficult airway. An international Delphi study.Intensive care medicine · 2024Article
- [Prehospital postcardiac-arrest-sedation and -care in the Federal Republic of Germany-a web-based survey of emergency physicians].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Article
- Preoxygenation and apneic oxygenation in emergency airway management.Clinical and experimental emergency medicine · 2024Article
- Prehospital anesthesia in postcardiac arrest patients: a multicenter retrospective cohort study.European journal of medical research · 2024Observational
- Awake Tracheal Intubation Is Associated with Fewer Adverse Events in Critical Care Patients than Anaesthetised Tracheal Intubation.Journal of clinical medicine · 2023Article
- Is Provider Training Level Associated with First Pass Success of Endotracheal Intubation in the Pediatric Intensive Care Unit?Journal of pediatric intensive care · 2023Article
- Usability testing of a blind intubation device for intubation novices: a randomized crossover simulation study.Clinical and experimental emergency medicine · 2023Article
- Emergency airway management in a tertiary trauma centre (AIRMAN): a one-year prospective longitudinal study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023Observational
- Ramping Position to Aid Non-invasive Ventilation (NIV) in Obese Patients in the ICU.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2023Article
- A Systematic Review and Meta-Analysis of Randomized Controlled Trials on Supine vs. Nonsupine Endotracheal Intubation.Critical care research and practice · 2023Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe performed a systematic review of randomized controlled studies evaluating any drug, technique or device aimed at improving the success rate or safety of tracheal intubation in the critically ill.
methodsWe searched PubMed, BioMed Central, Embase and the Cochrane Central Register of Clinical Trials and references of retrieved articles. Finally, pertinent reviews were also scanned to detect further studies until May 2017. The following inclusion criteria were considered: tracheal intubation in adult critically ill patients; randomized controlled trial; study performed in Intensive Care Unit, Emergency Department or ordinary ward; and work published in the last 20 years. Exclusion criteria were pre-hospital or operating theatre settings and simulation-based studies. Two investigators selected studies for the final analysis. Extracted data included first author, publication year, characteristics of patients and clinical settings, intervention details, comparators and relevant outcomes. The risk of bias was assessed with the Cochrane Collaboration's Risk of Bias tool.
resultsWe identified 22 trials on use of a pre-procedure check-list (1 study), pre-oxygenation or apneic oxygenation (6 studies), sedatives (3 studies), neuromuscular blocking agents (1 study), patient positioning (1 study), video laryngoscopy (9 studies), and post-intubation lung recruitment (1 study). Pre-oxygenation with non-invasive ventilation (NIV) and/or high-flow nasal cannula (HFNC) showed a possible beneficial role. Post-intubation recruitment improved oxygenation
conclusionsThe limited available evidence supports a beneficial role of pre-oxygenation with NIV and HFNC before intubation of critically ill patients. Recruitment maneuvers may increase post-intubation oxygenation. Ramped position increased the number of intubation attempts; thiopental had negative hemodynamic effects and videolaryngoscopy might favor adverse events.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.