Evidence map›Paper›PMID 29351458›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2018

Differences in L-type Ca

Scott D Zawieja, Jorge A Castorena-Gonzalez, Joshua P Scallan, Michael J Davis

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
3.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 92 citations in OpenAlex.

  1. Article
  2. Pacemaking in the lymphatic system.The Journal of physiology · 2026
    Review
  3. Guidelines for evaluating endothelial function in vascular tissue.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  4. Article
  5. Lymphatic dysfunction is linked to disease pathogenesis in Duchenne muscular dystrophy animal models.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Regulation of Collecting Lymphatic Vessel Contractile Function by TRPV4 Channels.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Article
  8. Article
  9. Article
  10. Understanding the Lymphatic System: Tissue-on-Chip Modeling.Annual review of biomedical engineering · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Scott D ZawiejaDepartment of Medical Pharmacology and Physiology, University of Missouri , Columbia, Missouri.
Jorge A Castorena-GonzalezDepartment of Medical Pharmacology and Physiology, University of Missouri , Columbia, Missouri.
Joshua P ScallanMolecular Pharmacology and Physiology, University of South Florida , Tampa, Florida.
Michael J DavisDepartment of Medical Pharmacology and Physiology, University of Missouri , Columbia, Missouri.
University of Missouri · USUniversity of South Florida · US

Funding

Lymphatic pacemaking and pumping in lymphedema: function, dysfunction, and rescueR01HL122578 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI DAVIS, MICHAEL JOHN · 2015 to 2023
$4.1M
Transport Phenomena in the Lymphatic SystemU01HL123420 · NHLBI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI MOORE, JAMES E, ZAWIEJA, DAVID CARL · 2014 to 2018
$2.9M
Conduction and coordination of electrical signals within the lymphatic vascular wallR01HL125608 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI DAVIS, MICHAEL JOHN · 2015 to 2018
$1.6M
Mechanisms of lymphatic valve and pump dysfunction in lymphedemaR01HL120867 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI DAVIS, MICHAEL JOHN · 2014 to 2017
$1.5M
Lymphatic Endothelial Permeability as a Regulator of Mesenteric Adipose DepositioR00HL124142 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI SCALLAN, JOSHUA PAUL · 2016 to 2018
$717k
NHLBI NIH HHS R00 HL124142NHLBI NIH HHS R01 HL120867NHLBI NIH HHS R01 HL122578NHLBI NIH HHS R01 HL125608NHLBI NIH HHS U01 HL123420
6 · The paper itself

Abstract

We identified a regional dichotomy in murine lymphatic contractile function with regard to vessel location within the periphery or visceral cavity. All vessels isolated from peripheral regions [cervical, popliteal, inguinal, axillary, and internodal inguinal axillary (Ing-Ax)] developed robust contractions with maximal ejection fractions (EFs) of 50-80% in our ex vivo isobaric myograph experiments. Conversely, vessels isolated from the visceral cavity (mesenteric, thoracic duct, and iliac) demonstrated maximal EFs of ≤10%. Using pressure myography, sharp electrode membrane potential recordings, and Ca

Indexed as

Calcium SignalingMuscle Contraction3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl esterAction PotentialsAnimalsCalciumCalcium Channel AgonistsCalcium Channels, L-TypeDose-Response Relationship, DrugKineticsLymphatic VesselsMaleMice, Inbred C57BLMice, TransgenicMuscle, Smooth3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl esterCalciumCalcium Channel AgonistsCalcium Channels, L-Typelymphatic action potentiallymphatic muscle calciumlymphatic muscle membrane potentialmouse lymphatic contractionregional heterogeneity

Identifiers

PMID29351458
PMCPMC6008139
OpenAlexW2781506428

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.