Evidence map›Paper›PMID 29351457›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2018

Important role of endothelium-dependent hyperpolarization in the pulmonary microcirculation in male mice: implications for hypoxia-induced pulmonary hypertension.

Shuhei Tanaka, Takashi Shiroto, Shigeo Godo, Hiroki Saito, Yosuke Ikumi, Akiyo Ito, Shoko Kajitani, Saori Sato, Hiroaki Shimokawa

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In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  4. Article
  5. Review
  6. The Yin and Yang of endothelium-derived vasodilator factors.American journal of physiology. Heart and circulatory physiology · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Shuhei TanakaDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan.
Takashi ShirotoDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan.
Shigeo GodoDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan.
Hiroki SaitoDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan.
Yosuke IkumiDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan.
Akiyo ItoDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan.
Shoko KajitaniDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan.
Saori SatoDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan.
Hiroaki ShimokawaDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan.
Tohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endothelium-dependent hyperpolarization (EDH) plays important roles in the systemic circulation, whereas its role in the pulmonary circulation remains largely unknown. Furthermore, the underlying mechanisms of pulmonary hypertension (PH) also remain to be elucidated. We thus aimed to elucidate the role of EDH in pulmonary circulation in general and in PH in particular. In isolated perfused lung and using male wild-type mice, endothelium-dependent relaxation to bradykinin (BK) was significantly reduced in the presence of N

Indexed as

MicrocirculationPulmonary CirculationVasodilationAnimalsBiological FactorsDisease Models, AnimalEndothelium, VascularHypertension, PulmonaryHypoxiaMaleMembrane PotentialsMice, Inbred C57BLNitric OxidePulmonary ArterySignal TransductionTyrosine3-nitrotyrosineBiological Factorsendothelium-dependent hyperpolarization factorNitric OxideTyrosineVasodilator Agentsendothelium-dependent hyperpolarizationhypoxiapulmonary microcirculation

Identifiers

PMID29351457
OpenAlexW2782022531

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.