Evidence map›Paper›PMID 29351415›Full record

ArticleAmerican journal of physiology. Cell physiology2018

AMP-activated protein kinase and adenosine are both metabolic modulators that regulate chloride secretion in the shark rectal gland ( Squalus acanthias).

Rugina I Neuman, Juliette A M van Kalmthout, Daniel J Pfau, Dhariyat M Menendez, Lawrence H Young, John N Forrest

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rugina I NeumanDepartment of Internal Medicine, Yale University School of Medicine , New Haven, Connecticut.
Juliette A M van KalmthoutDepartment of Internal Medicine, Yale University School of Medicine , New Haven, Connecticut.
Daniel J PfauDepartment of Internal Medicine, Yale University School of Medicine , New Haven, Connecticut.
Dhariyat M MenendezThe Mount Desert Island Biological Laboratory, Salisbury Cove, Maine.
Lawrence H YoungDepartment of Internal Medicine, Yale University School of Medicine , New Haven, Connecticut.
John N ForrestDepartment of Internal Medicine, Yale University School of Medicine , New Haven, Connecticut.
Mount Desert Island Biological Laboratory · USYale University · US

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI Dustin Lynn Updike · 2012 to 2026
$60.0M
THE EPITHELIA OF THE EYE--EFFECT OF ENVIRONMENTAL AGENTSP30ES003828 · NIEHS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI HENSON, JOHN H · 1987 to 2008
$4.1M
ADENOSINE RECEPTORS AND ION TRANSPORT IN EPITHELIAR01DK034208 · NIDDK · YALE UNIVERSITY · PI FORREST, JOHN N · 1986 to 2003
$1.6M
NIDDK NIH HHS R01 DK034208NIEHS NIH HHS P30 ES003828NIGMS NIH HHS P20 GM103423
6 · The paper itself

Abstract

The production of endogenous adenosine during secretagogue stimulation of CFTR leads to feedback inhibition limiting further chloride secretion in the rectal gland of the dogfish shark (Squalus acanthias). In the present study, we examined the role of AMP-kinase (AMPK) as an energy sensor also modulating chloride secretion through CFTR. We found that glands perfused with forskolin and isobutylmethylxanthine (F + I), potent stimulators of chloride secretion in this ancient model, caused significant phosphorylation of the catalytic subunit Thr

Indexed as

Energy MetabolismAdenosineAminoimidazole CarboxamideAMP-Activated Protein KinasesAnimalsCell HypoxiaChloridesCystic Fibrosis Transmembrane Conductance RegulatorEnzyme ActivationEnzyme ActivatorsFish ProteinsPerfusionPhosphorylationProtein SubunitsRibonucleotidesSalt GlandAdenosineAICA ribonucleotideAminoimidazole CarboxamideAMP-Activated Protein KinasesChloridesCystic Fibrosis Transmembrane Conductance RegulatorEnzyme ActivatorsFish ProteinsProtein SubunitsRibonucleotidesadenosineAMPKCFTRchloride secretionshark rectal glandSqualus acanthias

Identifiers

PMID29351415
PMCPMC5966785
OpenAlexW2778755882

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.