ArticleAmerican journal of physiology. Cell physiology2018
Hypoxia selectively upregulates cation channels and increases cytosolic [Ca
Open access · bronzeAbstract readComparative Study
In one paragraph
Article in American journal of physiology. Cell physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- The Role of Metal Ions in Mitochondria: From Energy Metabolism to Cell Destiny.Biological trace element research · 2026Review
- Altitude hypoxia and hypoxemia: pathogenesis and management.Signal transduction and targeted therapy · 2026Review
- Tissue metabolomics reveals metabolic dysregulation associated with intimal hyperplasia in arteriovenous fistula stenosis.Frontiers in physiology · 2025Article
- Nupr1-mediated vascular smooth muscle cell phenotype transformation involved in methamphetamine induces pulmonary hypertension.Cell biology and toxicology · 2024Article
- Transient Receptor Potential Canonical 6 (TRPC6) Channel in the Pathogenesis of Diseases: A Jack of Many Trades.Inflammation · 2023Review
- MiR-205-5p Functions as a Tumor Suppressor in Gastric Cancer Cells through Downregulating FAM84B.Journal of oncology · 2022Article
- Role of Store-Operated CaBiomolecules · 2021Review
- Amelioration of circadian disruption and calcium-handling protein defects by choline alleviates cardiac remodeling in abdominal aorta coarctation rats.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- NEDD9, a Hypoxia-upregulated Mediator for Pathogenic Platelet-Endothelial Cell Interaction in Pulmonary Hypertension.American journal of respiratory and critical care medicine · 2021Article
- Store-Operated Calcium Entry in the Cardiovascular System.Advances in experimental medicine and biology · 2021Review
- NF-κB/p65 Competes With Peroxisome Proliferator-Activated Receptor Gamma for Transient Receptor Potential Channel 6 in Hypoxia-Induced Human Pulmonary Arterial Smooth Muscle Cells.Frontiers in cell and developmental biology · 2021Article
- The Action of 2-Aminoethyldiphenyl Borinate on the Pulmonary Arterial Hypertension and Remodeling of High-Altitude Hypoxemic Lambs.Frontiers in physiology · 2021Article
- P53 in the impaired lungs.DNA repair · 2020Review
- Vasoconstrictor Mechanisms in Chronic Hypoxia-Induced Pulmonary Hypertension: Role of Oxidant Signaling.Antioxidants (Basel, Switzerland) · 2020Review
- The Role and Regulation of Pulmonary Artery Smooth Muscle Cells in Pulmonary Hypertension.International journal of hypertension · 2020Review
- Focus on Early Events: Pathogenesis of Pulmonary Arterial Hypertension Development.Antioxidants & redox signaling · 2019Review
- ORAI channels in cellular remodeling of cardiorespiratory disease.Cell calcium · 2019Review
- Revisiting the Role of TRP, Orai, and ASIC Channels in the Pulmonary Arterial Response to Hypoxia.Frontiers in physiology · 2018Review
- Long-term chronic intermittent hypoxia: a particular form of chronic high-altitude pulmonary hypertension.Pulmonary circulationReview
- Stim-activated TRPC-ORAI channels in pulmonary hypertension induced by chronic intermittent hypoxia.Pulmonary circulationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Xi HeDepartment of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an, Shannxi Province, China.
Shanshan SongDivision of Translational and Regenerative Medicine, Department of Medicine, The University of Arizona College of Medicine , Tucson, Arizona.
Ramon J AyonDivision of Translational and Regenerative Medicine, Department of Medicine, The University of Arizona College of Medicine , Tucson, Arizona.
Angela BalisterieriDivision of Translational and Regenerative Medicine, Department of Medicine, The University of Arizona College of Medicine , Tucson, Arizona.
Stephen M BlackDivision of Translational and Regenerative Medicine, Department of Medicine, The University of Arizona College of Medicine , Tucson, Arizona.
Ayako MakinoDivision of Translational and Regenerative Medicine, Department of Medicine, The University of Arizona College of Medicine , Tucson, Arizona.
W Gil WierDepartment of Physiology, The University of Arizona College of Medicine , Tucson, Arizona.
Wei-Jin ZangDepartment of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an, Shannxi Province, China.
Jason X-J YuanDivision of Translational and Regenerative Medicine, Department of Medicine, The University of Arizona College of Medicine , Tucson, Arizona.
University of Arizona · USXi'an Jiaotong University · CN
Funding
SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7MProtein Chemistry & Biophysics CoreP01HL134610 · NHLBI · UNIVERSITY OF ARIZONA · PI BLACK, STEPHEN M · 2018 to 2022
$11.6MIon Channels and Membrane Receptors in Pulmonary Arterial HypertensionR35HL135807 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YUAN, JASON X J · 2017 to 2023
$5.6MNa+/Ca2+ Exchanger type-1 in Arterial Contraction and Salt-induced HypertensionR01HL107654 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI WIER, WITHROW GIL · 2011 to 2015
$1.8MPhenomic and genomic study to subphenotype Hispanics with pulmonary hypertensionU01HL125208 · NHLBI · UNIVERSITY OF ARIZONA · PI GARCIA, JOE G. N., RISCHARD, FRANZ P · 2014 to 2018
$1.5MNHLBI NIH HHS P01 HL134610NHLBI NIH HHS R01 HL107654NHLBI NIH HHS R35 HL135807NHLBI NIH HHS U01 HL125208NIEHS NIH HHS P30 ES006694
Abstract
Ca
Indexed as
Calcium SignalingCalciumCalcium ChannelsCell HypoxiaCells, CulturedCoronary VesselsEnergy MetabolismHumansKineticsMembrane PotentialsMuscle, Smooth, VascularMyocytes, Smooth MuscleNeoplasm ProteinsORAI1 ProteinPulmonary ArteryStromal Interaction Molecule 1CalciumCalcium ChannelsNeoplasm ProteinsORAI1 ProteinORAI1 protein, humanSTIM1 protein, humanStromal Interaction Molecule 1TRPC6 Cation ChannelTRPC6 protein, humancalcium signalingcoronary vasodilationhypoxiahypoxic pulmonary vasoconstriction
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.