Evidence map›Paper›PMID 29351404›Full record

ArticleAmerican journal of physiology. Cell physiology2018

Type 2 diabetes impairs the ability of skeletal muscle pericytes to augment postischemic neovascularization in db/db mice.

Katherine L Hayes, Louis M Messina, Lawrence M Schwartz, Jinglian Yan, Amy S Burnside, Sarah Witkowski

Open access · hybridAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Optimization of a pericyte therapy to improve muscle recovery after limb immobilization.Journal of applied physiology (Bethesda, Md. : 1985) · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Metabolic Coordination of Pericyte Phenotypes: Therapeutic Implications.Frontiers in cell and developmental biology · 2020
    Review
  12. Pericyte transplantation improves skeletal muscle recovery following hindlimb immobilization.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  13. The Role of the Stem Cells Therapy in the Peripheral Artery Disease.International journal of molecular sciences · 2019
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Katherine L HayesDepartment of Kinesiology, University of Massachusetts Amherst , Amherst, Massachusetts.
Louis M MessinaDiabetes Center of Excellence and Division of Vascular and Endovascular Surgery, University of Massachusetts Medical School , Worcester, Massachusetts.
Lawrence M SchwartzDepartment of Biology, University of Massachusetts Amherst , Amherst, Massachusetts.
Jinglian YanDiabetes Center of Excellence and Division of Vascular and Endovascular Surgery, University of Massachusetts Medical School , Worcester, Massachusetts.
Amy S BurnsideFlow Cytometry Core Facility, Institute for Applied Life Sciences, University of Massachusetts Amherst , Amherst, Massachusetts.
Sarah WitkowskiDepartment of Kinesiology, University of Massachusetts Amherst , Amherst, Massachusetts.
University of Massachusetts Amherst · USUniversity of Massachusetts Chan Medical School · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral artery disease is an atherosclerotic occlusive disease that causes limb ischemia and has few effective noninterventional treatments. Stem cell therapy is promising, but concomitant diabetes may limit its effectiveness. We evaluated the therapeutic potential of skeletal muscle pericytes to augment postischemic neovascularization in wild-type and type 2 diabetic (T2DM) mice. Wild-type C57BL/6J and leptin receptor spontaneous mutation db/db T2DM mice underwent unilateral femoral artery excision to induce limb ischemia. Twenty-four hours after ischemia induction, CD45

Indexed as

Neovascularization, PhysiologicAnimalsCell DifferentiationCells, CulturedCollateral CirculationDiabetes Mellitus, Type 2Disease Models, AnimalHumansInsulinIschemiaMaleMice, Inbred C57BLMice, Mutant StrainsMuscle, SkeletalMutationPericytesInsulinleptin receptor, mouseReceptors, Leptinlimb ischemiapericytesSchwann cellstype 2 diabetes

Identifiers

PMID29351404
PMCPMC6008064
OpenAlexW2784162871

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.