Evidence map›Paper›PMID 29351393›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2018

Liver tissue metabolically transformed by alcohol induces immune recognition of liver self-proteins but not in vivo inflammation.

Michael J Duryee, Benjamin M Wiese, Jordan R Bowman, Jared D Vanlandingham, Lynell W Klassen, Geoffrey E Thiele, Carlos D Hunter, Daniel R Anderson, Ted R Mikuls, Geoffrey M Thiele

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Best Practices and Progress in Precision-Cut Liver Slice Cultures.International journal of molecular sciences · 2021
    Review
  2. Pathogenesis of Alcohol-Associated Liver Disease.Journal of clinical and experimental hepatology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Michael J DuryeeExperimental Immunology Laboratory, Division of Rheumatology and Immunology, Department of Internal Medicine, University of Nebraska Medical Center , Omaha, Nebraska.
Benjamin M WieseExperimental Immunology Laboratory, Division of Rheumatology and Immunology, Department of Internal Medicine, University of Nebraska Medical Center , Omaha, Nebraska.
Jordan R BowmanExperimental Immunology Laboratory, Division of Rheumatology and Immunology, Department of Internal Medicine, University of Nebraska Medical Center , Omaha, Nebraska.
Jared D VanlandinghamExperimental Immunology Laboratory, Division of Rheumatology and Immunology, Department of Internal Medicine, University of Nebraska Medical Center , Omaha, Nebraska.
Lynell W KlassenExperimental Immunology Laboratory, Division of Rheumatology and Immunology, Department of Internal Medicine, University of Nebraska Medical Center , Omaha, Nebraska.
Geoffrey E ThieleExperimental Immunology Laboratory, Division of Rheumatology and Immunology, Department of Internal Medicine, University of Nebraska Medical Center , Omaha, Nebraska.
Carlos D HunterExperimental Immunology Laboratory, Division of Rheumatology and Immunology, Department of Internal Medicine, University of Nebraska Medical Center , Omaha, Nebraska.
Daniel R AndersonExperimental Immunology, Division of Cardiology, Department of Internal Medicine, Research in Cardiovascular Disease Laboratory at the University of Nebraska Medical Center , Omaha, Nebraska.
Ted R MikulsExperimental Immunology Laboratory, Division of Rheumatology and Immunology, Department of Internal Medicine, University of Nebraska Medical Center , Omaha, Nebraska.
Geoffrey M ThieleExperimental Immunology Laboratory, Division of Rheumatology and Immunology, Department of Internal Medicine, University of Nebraska Medical Center , Omaha, Nebraska.
University of Nebraska Medical Center · USVA Nebraska Western Iowa Health Care System · US

Funding

Tracking and Evaluation CoreU54GM115458 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI HOLSTEIN, SARAH A · 2016 to 2025
$42.8M
ALCOHOL AND LIVER ENDOTHELIAL CELLS IN IMMUNE RESPONSESR01AA010435 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI THIELE, GEOFFREY MILTON · 2000 to 2011
$2.5M
IMMUNE RESPONSES TO ACETALDEHYDE ADDUCTSR37AA007818 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KLASSEN, LYNELL W. · 1999 to 2008
$2.3M
The Role of Rho GTPases in Ethanol-Induced Liver InjuryR21AA015505 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SCHAFFERT, COURTNEY S · 2006 to 2007
$325k
NIAAA NIH HHS R01 AA010435NIAAA NIH HHS R21 AA015505NIAAA NIH HHS R37 AA007818NIGMS NIH HHS U54 GM115458
6 · The paper itself

Abstract

Precision-cut liver slices (PCLSs) provide a novel model for studies of alcoholic liver disease (ALD). This is relevant, as in vivo ethanol exposure does not appear to generate significant liver damage in ethanol-fed mice, except in the National Institute on Alcohol Abuse and Alcoholism binge model of ALD. Previous studies have shown that the two metabolites of ethanol consumption, malondialdhyde (MDA) and acetaldehyde (AA), combine to form MDA-AA (MAA) adducts, which have been correlated with the development and progression of ALD. In this study, murine PCLSs were incubated with ethanol and examined for the production of MAA adducts. PCLSs were homogenized, and homogenates were injected into C57BL/6 mice. PCLSs from control-, pair-, and ethanol-fed animals served as targets in in situ cytotoxic assays using primed T cells from mice hyperimmunized with control or ethanol-exposed PCLS homogenates. A CD45.1/CD45.2 passive-transfer model was used to determine whether T cells from the spleens of mice hyperimmunized with PCLS ethanol-exposed homogenates trafficked to the liver. PCLSs incubated with ethanol generated MAA-modified proteins in situ. Cytotoxic (CD8

Indexed as

AutoimmunityAcetaldehydeAdoptive TransferAnimalsCell MovementCells, CulturedDisease Models, AnimalFatty Liver, AlcoholicFemaleHumansInterleukin-6In Vitro TechniquesLeukocyte Common AntigensLiverLiver Diseases, AlcoholicLymphocyte ActivationAcetaldehydeInterleukin-6interleukin-6, mouseLeukocyte Common AntigensMalondialdehydePtprc protein, mousealcoholic liver diseaseantibodyin vitro inflammationlivermalondialdehyde-acetaldehyde adductsprecision-cut liver slicesprotein adductsT cell transfer

Identifiers

PMID29351393
PMCPMC5899239
OpenAlexW2777429978

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.