Evidence map›Paper›PMID 29351390›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2018

Vagally mediated gastric effects of brain stem α

Yanyan Jiang, Kirsteen N Browning, Luca Toti, R Alberto Travagli

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Stress-induced neuroplasticity in the gastric response to brainstem oxytocin in male rats.American journal of physiology. Gastrointestinal and liver physiology · 2022
    Article
  4. Review
  5. Article
  6. Sex differences in GABAergic neurotransmission to rat DMV neurons.American journal of physiology. Gastrointestinal and liver physiology · 2019
    Article
  7. Role of estrogen and stress on the brain-gut axis.American journal of physiology. Gastrointestinal and liver physiology · 2019
    Review
  8. Stomaching Acute Brain Injury.Neurocritical care · 2019
    Article
  9. Advances in the physiology of gastric emptying.Neurogastroenterology and motility · 2019
    Review
  10. Central control of gastrointestinal motility.Current opinion in endocrinology, diabetes, and obesity · 2019
    Review
  11. Article
  12. Novel transmitters in brain stem vagal neurocircuitry: new players on the pitch.American journal of physiology. Gastrointestinal and liver physiology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yanyan JiangDepartment of Neural and Behavioral Sciences, Penn State, College of Medicine , Hershey, Pennsylvania.
Kirsteen N BrowningDepartment of Neural and Behavioral Sciences, Penn State, College of Medicine , Hershey, Pennsylvania.ORCID 0000-0002-5062-3703
Luca TotiDepartment of Neural and Behavioral Sciences, Penn State, College of Medicine , Hershey, Pennsylvania.
R Alberto TravagliDepartment of Neural and Behavioral Sciences, Penn State, College of Medicine , Hershey, Pennsylvania.ORCID 0000-0003-2297-7683
Penn State Milton S. Hershey Medical Center · US

Funding

BRAINSTEM CIRCUITS CONTROLLING GASTROINTESTINAL FUNCTIONR01DK055530 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROWNING, KIRSTEEN NAIRN · 1998 to 2020
$4.6M
The effects of glucose on central vagal brainstem circuitsR01DK078364 · NIDDK · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI BROWNING, KIRSTEEN NAIRN · 2010 to 2014
$1.4M
NIDDK NIH HHS R01 DK055530NIDDK NIH HHS R01 DK078364
6 · The paper itself

Abstract

Chronic stress exerts vagally dependent effects to disrupt gastric motility; previous studies have shown that, among other nuclei, A2 neurons are involved in mediating these effects. Several studies have also shown robust in vitro and in vivo effects of α2-adrenoceptor agonists on vagal motoneurons. We have demonstrated previously that brainstem vagal neurocircuits undergo remodeling following acute stress; however, the effects following brief periods of chronic stress have not been investigated. Our aim, therefore, was to test the hypothesis that different types of chronic stress influence gastric tone and motility by inducing plasticity in the response of vagal neurocircuits to α

Indexed as

Gastrointestinal MotilityMotor NeuronsStomachAdrenergic alpha-AgonistsAnimalsBrain StemCatecholaminesNeuronal PlasticityRatsRats, Sprague-DawleyReceptors, Adrenergic, alphaStress, PhysiologicalVagus NerveAdrenergic alpha-AgonistsCatecholaminesReceptors, Adrenergic, alphacatecholaminesneurogastroenterologystomachstressvagus

Identifiers

PMID29351390
PMCPMC5966751
OpenAlexW2783549979

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.